000 -LEADER |
fixed length control field |
a |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20190315101447.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
190312b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
AIKTC-KRRC |
Transcribing agency |
AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME |
9 (RLIN) |
7998 |
Author |
Shehzadi, N. |
245 ## - TITLE STATEMENT |
Title |
Radical scavenging and endogenous defence system inducing activities of 5-[(4-Chlorophenoxy) methyI]-1,3.4-oxadiazole-2-thiol: A novel antioxidant |
250 ## - EDITION STATEMENT |
Volume, Issue number |
Vol. 80(6), November-December |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
Mumbai |
Year |
2018 |
Name of publisher, distributor, etc. |
Indian Journal of Pharmaceutical Science |
300 ## - PHYSICAL DESCRIPTION |
Pagination |
1125-1135 |
520 ## - SUMMARY, ETC. |
Summary, etc. |
5-[(4-Chlorophenoxy)methyl]-1,3,4-oxadiazole-2-thiol owing to the presence of –SH group is expected to have a significant reducing potential, which could be translated into antioxidant activity and to prove this, the present study explored the antioxidant potential and binding pattern of this compound to oxidative stress-related protein targets. The antioxidant properties were determined using in vitro methods with ascorbic acid and butylated hydroxytoluene as standards while interactions of 5-[(4-chlorophenoxy)methyl]-1,3,4-oxadiazole-2-thiol with protein tyrosine kinase 2-β and glutathione reductase were determined using online software, Mcule 1-Click Docking, 3DLigandSite and COACH. The antioxidant activity of 5-[(4-chlorophenoxy)methyl]-1,3,4-oxadiazole-2-thiol was found to be 89.30±0.013, 81.20±0.002, 80.52±0.016, 54.81±0.007, 52.87±0.008, 34.44±0.019 and 19.91±0.014 % in hydrogen peroxide scavenging assay, 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay, phosphomolybdenum assay, nitric oxide scavenging assay, reducing power assay, ferric thiocyanate assay and β-carotene bleaching assay, respectively. In all these assays, EC50 of 5-[(4-chlorophenoxy)methyl]-1,3,4-oxadiazole-2-thiol ranged from 0.32-0.93 mg/ml. The docking results indicated excellent binding to protein tyrosine kinase 2-β and glutathione reductase, maximum for the latter. The results of the present study revealed that 5-[(4-chlorophenoxy)methyl]-1,3,4-oxadiazole-2-thiol has the propensity to abrogate oxidation by inducing endogenous defence system and preventing radical chain reactions, hence might be considered a potential antioxidant for further investigations. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
9 (RLIN) |
4639 |
Topical term or geographic name entry element |
PHARMACEUTICS |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
7999 |
Co-Author |
Hussain, K. |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
8000 |
Co-Author |
Khan, M. T. |
773 0# - HOST ITEM ENTRY |
Place, publisher, and date of publication |
New Delhi Indian Pharmaceutical Association |
International Standard Serial Number |
0250-474X |
Title |
Indian journal of pharmaceutical sciences |
856 ## - ELECTRONIC LOCATION AND ACCESS |
URL |
http://www.ijpsonline.com/articles/radical-scavenging-and-endogenous-defence-system-inducing-activities-of-54chlorophenoxymethyl134oxadiazole2thiol-a-novel-antioxida-3572.html |
Link text |
Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Koha item type |
Articles Abstract Database |