| 000 -LEADER |
|---|
| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20190514115932.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
190324b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8210 |
| Author |
Sabu, Priyanka |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Efficacy ratio: A tool to enhance optimal antimicrobial use for intra‑abdominal infections |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol. 50(6), November-December |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Mumbai |
| Name of publisher, distributor, etc. |
Wolter Kluwer |
| Year |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
332-335p. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
BACKGROUND: Antimicrobial resistance and inappropriate antibiotic regimen hamper a favorable outcome in intra‑abdominal infections. Clinicians rely on the minimum inhibitory concentration (MIC) value to choose from the susceptible antimicrobials. However, the MIC values cannot be directly compared between the different antibiotics because their breakpoints are different. For that reason, efficacy ratio (ER), a ratio of susceptible MIC breakpoint and MIC of isolate, can be used to choose the most appropriate antimicrobial.MATERIALS AND METHODS: A prospective, observational study conducted during 2015 and 2016 included 356 Escherichiacoli and 158 Klebsiella spp. isolates obtained from the intra‑abdominal specimens. MIC was determined by microbroth dilution method, and ER of each antibiotic was calculated for all the isolates.RESULTS: For both E. coli and Klebsiella spp., ertapenem, amikacin, and piperacillin/tazobactam had the best activities among their respective antibiotic classes.DISCUSSION: This is the first study calculating ER for deciding empiric treatment choices. ER also has a potential additional value in choosing the use of susceptible drugs as monotherapy or combination therapy. A shift in ERs over a period of time tracks rising MIC values and predicts antimicrobial resistance development.CONCLUSION: Estimation of ER could be a meaningful addition for the interpretation of an antimicrobial susceptibility report, thus helping the physician to choose the best among susceptible antimicrobials for patient manageme |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
4774 |
| Topical term or geographic name entry element |
PHARMACOLOGY |
| 653 ## - Keywords |
|---|
| Keywords |
Antimicrobials, , , |
| 653 ## - Keywords |
|---|
| Keywords |
Efficacy ratio |
| 653 ## - Keywords |
|---|
| Keywords |
Ertapenem |
| 653 ## - Keywords |
|---|
| Keywords |
Gram‑negative organisms |
| 653 ## - Keywords |
|---|
| Keywords |
Minimum inhibitory concentration |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8211 |
| Co-Author |
Elangovan, Divyaa |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8212 |
| Co-Author |
Pragasam, Agila Kumari |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Indian Journal of Pharmacology |
| International Standard Serial Number |
0253-7613 |
| Place, publisher, and date of publication |
Andheri - Mumbai Wolters Kluwer India Private Limited |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
http://www.ijp-online.com/temp/IndianJPharmacol506332-1085263_030052.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
