000 -LEADER |
fixed length control field |
a |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20190513105111.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
190513b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
AIKTC-KRRC |
Transcribing agency |
AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME |
9 (RLIN) |
8452 |
Author |
Jose, C. A. |
245 ## - TITLE STATEMENT |
Title |
Hydrotropic solubilisation of irbesartan: Mechanistic study and dissolution porfiling |
250 ## - EDITION STATEMENT |
Volume, Issue number |
Vol. 56(03), March |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
Mumbai |
Name of publisher, distributor, etc. |
Indian Drug Manufacturers Association |
Year |
2019 |
300 ## - PHYSICAL DESCRIPTION |
Pagination |
74-76p. |
520 ## - SUMMARY, ETC. |
Summary, etc. |
Irbesartan (IB) is a water insoluble drug belonging to BCS II that exerts its anti-hypertensive effect through the blockage of angiotensin II receptors. The aqueous insolubility of IB limits its bioavailability and overall efficacy. Hydrotrophy, a solubilization technique to achieve an augmentation in aqueous solubility of poorly water-soluble drugs, has recently gained a lot of interest due to its safety, economics, and use of non-toxic and non-flammable adjuvants. The present study deals with application of hydrotrophy techniques to increase the solubility of IB using sodium benzoate and urea as the hydrotropic agent. The results showed a significant enhancement in dissolution profile of IB as compared to non-hydrotropic drug. The dissolution rate and solubility comparison of both hydrotropic agents revealed that sodium benzoate has a better solubilizing efficiency than urea. Hence, it can be concluded that hydrotropic concept can be adopted as a solubility enhancement technique for poorly water-soluble drugs. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
9 (RLIN) |
5021 |
Topical term or geographic name entry element |
DRUG STORE MANAGEMENT |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
8453 |
Co-Author |
Amra, K. B. |
773 0# - HOST ITEM ENTRY |
Place, publisher, and date of publication |
Mumbai Indian Drug Manufactures Association |
Title |
Indian drugs |
856 ## - ELECTRONIC LOCATION AND ACCESS |
URL |
https://www.indiandrugsonline.org/issuesarticle-details?id=OTE0 |
Link text |
Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Koha item type |
Articles Abstract Database |