| 000 -LEADER |
|---|
| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20190514103052.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
190514b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8478 |
| Author |
Thakkar, Hetal P. |
| 245 ## - TITLE STATEMENT |
|---|
| Title |
Influence of Inclusion Complexation and Skin Microporation on Enhancement of Transdermal Permeation of Raloxifene Hydrochloride |
| 250 ## - EDITION STATEMENT |
|---|
| Volume, Issue number |
Vol. 81(1), Jan-Feb |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
Mumbai |
| Name of publisher, distributor, etc. |
Indian Journal of Pharmaceutical Science |
| Year |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Pagination |
22-31p. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
The aim of the present investigation was to develop an inclusion complex-based hydrogel for transdermal delivery of raloxifene hydrochloride. Inclusion complexation was tried using two types of cyclodextrins, β-cyclodextrin and hydroxypropyl-β-cyclodextrin. Kneading, co-precipitation, solvent evaporation and freeze drying were the methods explored for preparing inclusion complexes. The prepared complexes were characterized using differential scanning calorimetry, Fourier-transform infrared spectroscopy, X-ray powder diffraction and both in vitro and ex vivo drug release studies. Kneading method was found to be the most suitable for preparing the inclusion complexes. Phase solubility studies indicated that β-cyclodextrin gave rise to Bs type of curve while hydroxypropyl-β-cyclodextrin resulted in Ap type of curve. The stability constants (K1:1) obtained for β-cyclodextrin and hydroxypropyl-β-cyclodextrin were 1572 and 2960, respectively. Complexation efficiency of hydroxypropyl-β-cyclodextrin was higher than that of β-cyclodextrin. Differential scanning calorimetry, Fourier-transform infrared spectroscopy and X-ray powder diffraction studies indicated the superiority of hydroxypropyl-β-cyclodextrin for complexing raloxifene hydrochloride. In vitro and ex vivo studies showed that highest drug release occurred from inclusion complex prepared with hydroxypropyl-β-cyclodextrin with a ratio of 1:2.5. Histopathology studies revealed that the developed hydrogel was non-irritant and micropores were clearly visible for the microporated skin. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8479 |
| Co-Author |
Savsani, H. G. |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
|---|
| 9 (RLIN) |
8480 |
| Co-Author |
Srivastava, P. K. |
| 773 0# - HOST ITEM ENTRY |
|---|
| Title |
Indian journal of pharmaceutical sciences |
| Place, publisher, and date of publication |
New Delhi Indian Pharmaceutical Association |
| International Standard Serial Number |
0250-474X |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
|---|
| URL |
http://www.ijpsonline.com/articles/influence-of-inclusion-complexation-and-skin-microporation-on-enhancement-of-transdermal-permeation-of-raloxifene-hydroc.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
