Improved LC-MS/MS method development and validation for the determination of trandolapril and verapamil in human plasma (Record no. 9093)
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| 000 -LEADER | |
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| fixed length control field | a |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20190524112819.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 190524b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Original cataloging agency | AIKTC-KRRC |
| Transcribing agency | AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 8784 |
| Author | Yatha, Ravi |
| 245 ## - TITLE STATEMENT | |
| Title | Improved LC-MS/MS method development and validation for the determination of trandolapril and verapamil in human plasma |
| 250 ## - EDITION STATEMENT | |
| Volume, Issue number | Vol. 2(3) |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | M P |
| Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
| Year | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Pagination | 91-95p. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Objective: A simple, sensitive and rapid LC -MS/MS technique was developed for the quantitation of trandolapril (TDL) and verapamil (VPL) in a biological matrix and validated . Method s: Sample preparation processed by SPE (Solid Phase extraction ) on phenomenex cartridge using Ledipasvir as an internal standard. Two drugs were eluted on waters symmetry -RP 18 Result s: The quantification approach was validated in 5 -1500 ng /ml linear concentration range for TDL and 1 -2000 ng /ml for VPL. The intraday and inter -day precision and accuracy were found to be 0.58% to 5.69% and 93% to 104% for two drugs. The average recoveries for TDL and VPL were found to be 92.9% and 93.5% respectively. (5μ, 15 0 mm ×4. 0 mm ) column with the mobile composition of 10 mmol ammonium formate and ACN( acetonitrile ) in the ratio of 70:30 %V/V . Detection and quantitation were processed by electrospray ionization in positive ionization mode. Conclusio n: The developed work was validated and can be applicable to the routine analysis of TDL and VPL simultaneously in a biological matrix . |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| 9 (RLIN) | 4639 |
| Topical term or geographic name entry element | PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 8785 |
| Co-Author | Rajkamal, B. |
| 773 0# - HOST ITEM ENTRY | |
| International Standard Serial Number | 0975 – 1491 |
| Title | International journal of pharmacy and pharmaceutical science |
| Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/31247/19406 |
| Link text | Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Articles Abstract Database |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| School of Pharmacy | School of Pharmacy | Archieval Section | 2019-05-24 | 2018566 | 2019-06-19 | 2019-05-24 | Articles Abstract Database |