| 000 -LEADER |
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a |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20190529115519.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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190529b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
8924 |
| Author |
Soni, Nishant Kumar |
| 245 ## - TITLE STATEMENT |
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| Title |
Identification of a New Potential Reductase Inhibitor as an Anti-Tubercular Agent for Enoyl-Acp Reductase Inha Gene of Mycobacterium tuberculosis in Comparison with PT70 (5-Hexyl-2-(2-Methylphenoxy) Phenol) |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol. 52(4), Oct-Dec |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Bengaluru |
| Name of publisher, distributor, etc. |
Association of Pharmaceutical Teachers of India (APTI) |
| Year |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
691-698p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Bacterium Mycobacterium tuberculosis is the causative agent for the disease tuberculosis (TB) and is responsible for more than ten million different infections with an additional accountability for about two million deaths every year. PT70 molecule as described in the literature acts as a drug in the market, which has been utilized as a curative agent for the disease. However, for these commercialized anti-tuberculotic drugs the causative agent that is Mycobacterium tuberculosis is becoming drug resistant in a progressive manner. Therefore, to combat the metabolic activity of the bacteria there is a need for a potent drug that could be subjected to cure TB. The present study deals with the perspective of designing a novel inhibitor as an anti-tuberculotic agent for which PT70 has been taken as a base molecule, which is henceforth used in molecular docking with the target INHA gene, and as a result, the process observed a binding energy as -10.133. Comparative molecules were selected based on the process of pharmacophore modeling which were then docked with the receptor molecule. On concluding remarks, top five molecules were prioritized on the bases of their binding energy (highest as -10.881) as compared to the PT70 molecule. Therefore, all such molecules selected will be taken as drug like molecules in future, which can be used for inhibiting the INHA gene. The aforementionedfive molecules passed that ADMET analysis, membrane permeability test, pKa, and density function theory |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
8925 |
| Co-Author |
Verma, chandan Kumar |
| 773 0# - HOST ITEM ENTRY |
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| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title |
Indian journal of pharmaceutical education and research |
| International Standard Serial Number |
0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes_52_4_691_0.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
