000 -LEADER |
fixed length control field |
a |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20190919093342.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
190919b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
AIKTC-KRRC |
Transcribing agency |
AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME |
9 (RLIN) |
9536 |
Author |
Taran, T. H. |
245 ## - TITLE STATEMENT |
Title |
Synergistic Therapeutic Strategy of Dual Drug-loaded Lipid Polymer Hybrid Nanoparticles for Breast Cancer Treatment |
250 ## - EDITION STATEMENT |
Volume, Issue number |
Vol. 81(3), May-June |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
Mumabi |
Name of publisher, distributor, etc. |
Indian Journal of Pharmaceutical Science |
Year |
2019 |
300 ## - PHYSICAL DESCRIPTION |
Pagination |
474-482p. |
520 ## - SUMMARY, ETC. |
Summary, etc. |
In this investigation, a smart nanocarrier-loaded docetaxel, a microtubules disrupting agent and vorinostat, a histone deacetylase inhibitor was developed to achieve a synergistic anticancer effect. Dual drug-loaded lipid polymer hybrid nanoparticles were prepared, with easy fabrication and favourable properties including small size, narrow distribution and a high loading effi cacy. The in vitro drug release conducted in phosphate-buffered saline, pH 7.4 and acetate-buffered saline, pH 5.5 media demonstrated the sustained, pH-dependent release profi le. The nanoparticles were effectively taken up by cells, which ensured greater suppression of cell growth. The co-delivery of both drugs exhibited a synergistic effect on the induction of cancer cell apoptosis, resulting in greater inhibition of SCC-7, MCF-7, and MDA-MB-231 cancer cells by the drug-loaded carrier. These promising results may lead to clinical applications with enhanced docetaxel activity. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
9 (RLIN) |
4639 |
Topical term or geographic name entry element |
PHARMACEUTICS |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
9537 |
Co-Author |
Nguyen, H. T. |
773 0# - HOST ITEM ENTRY |
International Standard Serial Number |
0250-474X |
Place, publisher, and date of publication |
New Delhi Indian Pharmaceutical Association |
Title |
Indian journal of pharmaceutical sciences |
856 ## - ELECTRONIC LOCATION AND ACCESS |
URL |
http://www.ijpsonline.com/articles/synergistic-therapeutic-strategy-of-dual-drugloaded-lipid-polymer-hybrid-nanoparticles-for-breast-cancer-treatment.pdf |
Link text |
Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Koha item type |
Articles Abstract Database |