000 -LEADER |
fixed length control field |
a |
003 - CONTROL NUMBER IDENTIFIER |
control field |
OSt |
005 - DATE AND TIME OF LATEST TRANSACTION |
control field |
20191018150313.0 |
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
fixed length control field |
191018b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE |
Original cataloging agency |
AIKTC-KRRC |
Transcribing agency |
AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME |
9 (RLIN) |
9946 |
Author |
Argade, Pallavi |
245 ## - TITLE STATEMENT |
Title |
Liquisolid Compact Tablet of Candesartan Cilexetil with Enhanced Solubility using Neusilin US2, Aerosil 200 and Transcutol HP |
250 ## - EDITION STATEMENT |
Volume, Issue number |
Vol.53(30, Jul-Sep |
260 ## - PUBLICATION, DISTRIBUTION, ETC. |
Place of publication, distribution, etc. |
Karnataka |
Name of publisher, distributor, etc. |
Indian journal of pharmaceutical education and research |
Year |
2019 |
300 ## - PHYSICAL DESCRIPTION |
Pagination |
457-467p. |
520 ## - SUMMARY, ETC. |
Summary, etc. |
Objective: An attempt was made to enhance solubility, dissolution and intestinal permeability of drug candesartan cilexetil by liquisolid technology. Methods: Liquisolid tablet was formulated using non-volatile solvent Transcutol HP, carrier material Neusilin US2 and coating material Aerosil 200. Appropriate quantities of excipients were calculated with the help of mathematical model to get liquisolid powder. A 32 full-factorial design was used further to optimize liquisolid powder. Results: DSC, XRD and SEM studies revealed absence of crystalline nature of drug in liquisolid powder. Liquisolid powder was further compressed into tablet and subjected to various evaluation tests such as in-vitro drug release and ex-vivo intestinal permeation study. Conclusion: Liquisolid technology was found to be promising due to enhance solubility, dissolution and permeation of candesartan cilexetil by 19.75, 3.09 and 2.4-fold, respectively. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
9 (RLIN) |
4639 |
Topical term or geographic name entry element |
PHARMACEUTICS |
700 ## - ADDED ENTRY--PERSONAL NAME |
9 (RLIN) |
9947 |
Co-Author |
Patole, Vinita Chandrakant |
773 0# - HOST ITEM ENTRY |
Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
Title |
Indian journal of pharmaceutical education and research |
International Standard Serial Number |
0019-5464 |
856 ## - ELECTRONIC LOCATION AND ACCESS |
URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes_53_3_457_467.pdf |
Link text |
Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) |
Source of classification or shelving scheme |
|
Koha item type |
Articles Abstract Database |