In vitro evaluation of anti-cancer potential of A3 adenosine receptor agonist on A549 human lung cancer cell line (Record no. 9798)
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fixed length control field | a |
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control field | OSt |
005 - DATE AND TIME OF LATEST TRANSACTION | |
control field | 20191023151125.0 |
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fixed length control field | 191019b xxu||||| |||| 00| 0 eng d |
040 ## - CATALOGING SOURCE | |
Original cataloging agency | AIKTC-KRRC |
Transcribing agency | AIKTC-KRRC |
100 ## - MAIN ENTRY--PERSONAL NAME | |
9 (RLIN) | 10015 |
Author | Solanki, Nilay |
245 ## - TITLE STATEMENT | |
Title | In vitro evaluation of anti-cancer potential of A3 adenosine receptor agonist on A549 human lung cancer cell line |
250 ## - EDITION STATEMENT | |
Volume, Issue number | Vol. 11 (06) |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Place of publication, distribution, etc. | Bhopal |
Name of publisher, distributor, etc. | Innovare Academic Sciences Pvt Ltd |
Year | 2019 |
300 ## - PHYSICAL DESCRIPTION | |
Pagination | 109-111 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | The objective of this study was to evaluate the cytotoxic potential of A3AR agonist (ABMECA) against human lung cancer cell line A549 by using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay. Methods: Adenocarcinoma cell line A549 was used to assess MTT based cells viability. In vitro cytotoxic activity was evaluated for 3 different concentration of doxorubicin and A3AR by MTT cytotoxicity assay. Cytotoxicity assay carried out for 3 consecutive days that involves culturing cells into Dulbecco’s MEM medium modified with 10% FBS for 24 h then treatment with different dose of standard and test drug with incubation period of 24 h followed by treatment with MTT for estimation of cytotoxicity and finally, optical density (OD) was measured at 570-630 nm. Results: Different concentration of doxorubicin (1, 5, 10 µM) and ABMECA (10-6M, 10-5M and 10-4M) shown dose-dependent cytotoxicity. There was a significant decrease (p<0.05) in cell viability in both doxorubicin and ABMECA concentration in a dose-dependent manner. This study may guide further for in vivo evaluation of test drug in the lung cancer model. Conclusion: A3 Adenosine Receptor agonist could be potential moiety for the treatment of lung cancer and it would require in vivo study for further research. |
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
9 (RLIN) | 4639 |
Topical term or geographic name entry element | PHARMACEUTICS |
700 ## - ADDED ENTRY--PERSONAL NAME | |
9 (RLIN) | 10016 |
Co-Author | Patel, Leena |
773 0# - HOST ITEM ENTRY | |
Place, publisher, and date of publication | Bhopal Innovare Academic Sciences Pvt Ltd |
International Standard Serial Number | 2656-0097 |
Title | International journal of pharmacy and pharmaceutical science |
856 ## - ELECTRONIC LOCATION AND ACCESS | |
URL | https://innovareacademics.in/journals/index.php/ijpps/article/view/30863 |
Link text | Click here |
942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
Source of classification or shelving scheme | |
Koha item type | Articles Abstract Database |
Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Barcode | Date last seen | Price effective from | Koha item type |
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School of Pharmacy | School of Pharmacy | Archieval Section | 2019-10-23 | 2019981 | 2019-10-23 | 2019-10-23 | Articles Abstract Database |