| 000 -LEADER |
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a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20191023085909.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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191023b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
10049 |
| Author |
Jamwal, Anupam |
| 245 ## - TITLE STATEMENT |
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| Title |
Antidiabetic Activity of Isolated Compound from Coccinia indica |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.53(1), Jan-Mar |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Bengaluru |
| Name of publisher, distributor, etc. |
Indian journal of pharmaceutical education and research |
| Year |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
151-159p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Background and Objective:Coccinia indica Wight. and Arn (Ivy gourd, family Cucurbitaceae) has a long tradition of use in the treatment of various ailments. Ayurveda and Unani systems claim C. indica as antidiabetic agent. Therefore the present investigation was aimed to evaluate antidiabetic activity of isolated compound(s) fromC. indica. Materials and Methods: Methanol extract of C. indica aerial parts was prepared by Soxhlet extraction method and ethyl acetate fraction was prepared by partitioning of methanol extract. Ethyl acetate fraction was subjected to antidiabetic activity-guided-fractionation using column chromatography for the isolation of antidiabetic compound(s). Various fractions and isolated compounds were screened for antidiabetic activity using streptozotocin-nicotinamide type-2 diabetic model. The glucose level in rats was determined using glucometer. The antidiabetic biochemical estimations were performed on bioactive isolated compound. Results: Bioactivity-guided-fractionation yielded a bio-flavonoid quercetin, which has been isolated for the first time from C. indica aerial parts. Quercetin (5 mg/kg, p.o.) significantly reduced the glucose levels in type-2 diabetic rats but did not produce hypoglycemic effects in oral glucose tolerance test on normal rats. Quercetin significantly increased insulin and serum HDL-cholesterol levels and showed better β-cell functions. Quercetin caused slight change in hepatic marker enzymes and kidney functions markers in diabetic rats. Conclusion: Quercetin is responsible for antidiabetic activity of C. indica aerial parts |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
10050 |
| Co-Author |
Suresh Kumar |
| 773 0# - HOST ITEM ENTRY |
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| International Standard Serial Number |
0019-5464 |
| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title |
Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes_53_1_151.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Articles Abstract Database |
