| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20191023103706.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
191023b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
10065 |
| Author |
Chauhan, Velenti |
| 245 ## - TITLE STATEMENT |
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| Title |
Development and Evaluation of Biodegradable Polymeric Based Long Acting in situ Forming Microparticles of LHRH Agonist Goserelin Acetate |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.53(20, Apr-Jun |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Bengaluru |
| Name of publisher, distributor, etc. |
Indian journal of pharmaceutical education and research |
| Year |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
216-224p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Aim: Goserelin acetate is parenterally administered, a typical LHRH analogue for the treatment of prostate cancer. The objective of present work was to formulate and evaluate long acting in situ forming microparticles of goserelin using PLGA which would extend the drug release. Materials and Methods: PLGA 50:50 were used as the biodegradable polymer, DMSO was as organic solvent and sesame oil was used as dispersion phase. HLB based system was used in present investigation for stabilizing non-aqueous emulsion prior to administration. Emulsifier mixtures of Span 80 and Tween 80 in different combination were prepared to stabilize microemulsion system with required HLB of external oil. Result: Developed microsphere batch E06 was found to be more stable with external phase ratio 2:8 were visualized under an inverted biological microscope. In vitro drug release profile of goserelin acetate was investigated that ISMs were minimized burst effect and release up to 24 days and it was found to be stable after 1 month. The drug release was observed 95.97%, 94.02% and 97.77% after 24 days in the batches A, B and C respectively of emulsion E06. Conclusion: ISMs of goserelin were successfully formulated and could be a potential substitute for a marketed formulation. The developed Biodegradable injectable in-situ microparticles (ISMs) were found to be optimized, formed stable, spherical and non- porous formulation |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
10066 |
| Co-Author |
Patel, Vimal |
| 773 0# - HOST ITEM ENTRY |
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| International Standard Serial Number |
0019-5464 |
| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title |
Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes_53_2_216.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
|
| Koha item type |
Articles Abstract Database |
