| 000 -LEADER |
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| fixed length control field |
a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20191023110203.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
191023b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
10069 |
| Author |
Wu, Jian |
| 245 ## - TITLE STATEMENT |
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| Title |
Pharmacokinetic Differences of Three Aconitum Alkaloids from Aconiti lateralis Radix Praeparata and Compatibility with Pinellia in Rats |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.53(2), Apr-Jun |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Bengaluru |
| Name of publisher, distributor, etc. |
Indian journal of pharmaceutical education and research |
| Year |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
236-241p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Aim: This study aims to develop a highly sensitive and specific UPLC-MS/MS method to explore the pharmacokinetic properties of three representative active alkaloids (benzoylhypaconine, benzoylmesaconine, benzoylaconine) after administration of extracts of Aconiti lateralis Radix Praeparata and compatibility with Pinellia, compare the influence of Pinellia on pharmacokinetic characterization of three aconitum alkaloids. Methods: Chromatographic separation were performed on a C18 column under the Multiple reaction monitoring (MRM) in the positive Electrospray ionization (ESI) mode. The pharmacokinetic parameters were evaluated by software DAS 3. 0.Results: The specificity, precision and accuracy,matrix effect and extraction recovery rate and stability all meet the requirements.The validation of the method was achieved in accordance to the FDA guidelines. After oral administration of the extract, similar tendency was found in the mean concentration of the three analytes in the curves, illustrating that three analytes exhibited a similar absorption and metabolic route. Compared the pharmacokinetic characteristics, the AUC0-t, AUC0-∞ and Cmax values of BMA and BHA in Fuzi group were lower than those in Fuzi-Banxia group. Conclusion: This finding indicated the significant statistical decrease (p<0.05) in the absorption of these components. After Banxia in combination with Fuzi, the results showed that faster absorption and higher exposure of BMA and BHA in rat plasma. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
10070 |
| Co-Author |
Li, Wen-Ian |
| 773 0# - HOST ITEM ENTRY |
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| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| International Standard Serial Number |
0019-5464 |
| Title |
Indian journal of pharmaceutical education and research |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes_53_2_236.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Articles Abstract Database |
