| 000 -LEADER |
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a |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20191023112436.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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191023b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
10073 |
| Author |
Sunmonu, Taofik Olatunde |
| 245 ## - TITLE STATEMENT |
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| Title |
Phytochemical Analysis, in vitro Antioxidant Activity and Inhibition of Key Diabetic Enzymes by Selected Nigerian Medicinal Plants with Antidiabetic Potential |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.53(2), Apr-Jun |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Bengaluru |
| Name of publisher, distributor, etc. |
Indian journal of pharmaceutical education and research |
| Year |
2019 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
250-260p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
Background: Diabetes is one of the most common metabolic disorders worldwide and the disease is generally believed to be incurable. However, the historical success of natural products as therapeutic agents has led to the search for more herbs with antidiabetic potential. Aim: To investigate the antioxidative and antidiabetic activities of some common medicinal plants traditionally used to treat diabetes in Nigeria. Materials and Methods: Twenty one plant samples comprising leaves, seeds and stem bark were separately extracted using three solvents of increasing polarity namely ethanol, methanol and distilled water. The extracts were subsequently screened for their phenolic profile, ferric reducing power as well as inhibition of α-amylase and haemoglobin glycosylation activities as markers of in vitro antidiabetic activity. Results: Solvents extracts of 7 out of the 21 plants examined namely Anacardium occidentale (leaf),Carica papaya (leaf), Ficus asperifolia (leaf),Hibiscus sabdariffa (stem bark), Khaya senegalensis (stem bark), Ocimum gratissimum (leaf) and Parkia biglobosa (stem bark) had significant concentrations of total polyphenol and flavonoid compared to the other plants. Similarly, for all the in vitro models used in this study, the same set of plants demonstrated significantly (p < 0.05) higher effects which were comparable to ascorbic acid, acarbose and gallic acid. Conclusion: Findings from this study indicate strong correlation between polyphenolic concentration and antidiabetic activity. The study also confirmed the potential of some Nigerian herbs in antidiabetic drug discovery; and identified a number of promising plants for further in vivo investigation as plant-based antidiabetic agents |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
10074 |
| Co-Author |
Lewu, Francis Bayo |
| 773 0# - HOST ITEM ENTRY |
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| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| Title |
Indian journal of pharmaceutical education and research |
| International Standard Serial Number |
0019-5464 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes_53_2_250.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Articles Abstract Database |
