Technological and Biopharmaceutical Characterization of Carbopol-Based Ketoprofen Emulgels (Record no. 9853)

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005 - DATE AND TIME OF LATEST TRANSACTION
control field 20191025143201.0
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040 ## - CATALOGING SOURCE
Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 10115
Author Peneva, Petya
245 ## - TITLE STATEMENT
Title Technological and Biopharmaceutical Characterization of Carbopol-Based Ketoprofen Emulgels
250 ## - EDITION STATEMENT
Volume, Issue number Vol.52(2), Apr-Jun
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Bengaluru
Name of publisher, distributor, etc. Indian journal of pharmaceutical education and research
Year 2018
300 ## - PHYSICAL DESCRIPTION
Pagination 212-217p.
520 ## - SUMMARY, ETC.
Summary, etc. Objective: Emulgels are a combination of emulsions and gels. In this study, the influence of different oil phases and gelling agent concentrations on the technological and biopharmaceutical characteristics of prepared emulgels is assessed. Materials and Methods: Light liquid paraffin (various concentrations), cetyl alcohol, isopropyl myristate, and almond oil were used in the oil phase of the emulsions, and Carbopol® 940 (0.5%, 0.75%, and 1% w/w concentrations) was used as the gelling agent for the gel base. The prepared emulgels were characterized in terms of pH, rheological behavior, spreadability, and in vitro release of ketoprofen. Results and Discussion: All formulations produced stable, white, semisolid forms with smooth homogeneous textures and no phase separations. The pH of the resulting emulgels ranged from 5.5 to 6.5. An increase in the carbopol concentration led to an increase in viscosity, and all prepared emulgels exhibited pseudoplastic flow. The spreadability of semisolid dosage forms improved by reducing the concentration of the gelling agent. Results from the in vitro study indicated that 88.48%-99.11% of the ketoprofen was released within 150 min. Conclusion: The prepared emulgels are in semisolid form, and hence suitable for topical application
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 4639
Topical term or geographic name entry element PHARMACEUTICS
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9 (RLIN) 10116
Co-Author Andonova, Velichka
773 0# - HOST ITEM ENTRY
Title Indian journal of pharmaceutical education and research
International Standard Serial Number 0019-5464
Place, publisher, and date of publication Bengluru Association of Pharmaceutical Teachers of India (APTI)
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URL https://www.ijper.org/sites/default/files/IndJPhaEdRes_52_2_212.pdf
Link text Click here
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Source of classification or shelving scheme
Koha item type Articles Abstract Database
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          School of Pharmacy School of Pharmacy Archieval Section 2019-10-25 2020003 2019-10-25 2019-10-25 Articles Abstract Database
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