| 000 -LEADER |
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a |
| 003 - CONTROL NUMBER IDENTIFIER |
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OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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20191025154343.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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191025b xxu||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE |
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AIKTC-KRRC |
| Transcribing agency |
AIKTC-KRRC |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
10140 |
| Author |
Sahu, Prafulla Kumar |
| 245 ## - TITLE STATEMENT |
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| Title |
Chemometric Assisted Ion-Pair Chromatography of Metaxolone and Diclofenac in Binary Mixture |
| Remainder of title |
:A Mechanistic Study |
| 250 ## - EDITION STATEMENT |
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| Volume, Issue number |
Vol.52(2), Apr-Jun |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
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| Place of publication, distribution, etc. |
Bengaluru |
| Name of publisher, distributor, etc. |
Indian journal of pharmaceutical education and research |
| Year |
2018 |
| 300 ## - PHYSICAL DESCRIPTION |
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| Pagination |
293-304p. |
| 520 ## - SUMMARY, ETC. |
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| Summary, etc. |
A reversed- phase high-performance liquid chromatographic (RP-HPLC) method based on ion pair formation is demonstrated for the simultaneous determination of Metaxalone (MTX) and Diclofenac potassium (DCP) in commercial formulations. MTX (pKa=12.24) and DCP (pKa=4.00) are hydrophilic ionic substances that make the separation critical due to distinct pKa values. Addition of ionic additives (ion-pairing reagents or chaotropic agents) to the mobile phase allowed a significant improvement in retention of the ionic analytes. However, finding the suitable condition of the Ion-Pair Chromatography(IPC) to achieve desirable separation was challenging and often rebellious to influential chromatographic parameters. The judicious selection of eluent pH, flow rate, acidic modifiers and organic modifier, detector wavelength was performed with the aid of Plackett–Burman design and Box–Behnken design. Desired separation of MTX and DCP was achieved using an Inertsil ODS2 (250x4.6mm; 5μm) column equilibrated with 10mM phosphatebuffer (pH-5.0): acetonitrile (42: 58%v/v) containing0.4%triethylamine and 0.5% tetrabutyl ammonium hydroxideas an eluent at a flow rate of 1.20 mL/min. Under optimal condition, the detection limits are 0.306μg/mL and 0.807μg/mL and limits of quantification 0.927μg/mL and 2.44μg/mL for MTX and DCP respectively. Subsequently, the plausible retention behavior of both analytes was predicted in the ion interaction condition. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
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| 9 (RLIN) |
4639 |
| Topical term or geographic name entry element |
PHARMACEUTICS |
| 700 ## - ADDED ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
10141 |
| Co-Author |
Panda, Jagadeesh |
| 773 0# - HOST ITEM ENTRY |
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| International Standard Serial Number |
0019-5464 |
| Title |
Indian journal of pharmaceutical education and research |
| Place, publisher, and date of publication |
Bengluru Association of Pharmaceutical Teachers of India (APTI) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS |
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| URL |
https://www.ijper.org/sites/default/files/IndJPhaEdRes_52_2_293.pdf |
| Link text |
Click here |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
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| Source of classification or shelving scheme |
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| Koha item type |
Articles Abstract Database |
