Chemometric Assisted Ion-Pair Chromatography of Metaxolone and Diclofenac in Binary Mixture (Record no. 9865)

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control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20191025154343.0
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fixed length control field 191025b xxu||||| |||| 00| 0 eng d
040 ## - CATALOGING SOURCE
Original cataloging agency AIKTC-KRRC
Transcribing agency AIKTC-KRRC
100 ## - MAIN ENTRY--PERSONAL NAME
9 (RLIN) 10140
Author Sahu, Prafulla Kumar
245 ## - TITLE STATEMENT
Title Chemometric Assisted Ion-Pair Chromatography of Metaxolone and Diclofenac in Binary Mixture
Remainder of title :A Mechanistic Study
250 ## - EDITION STATEMENT
Volume, Issue number Vol.52(2), Apr-Jun
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Bengaluru
Name of publisher, distributor, etc. Indian journal of pharmaceutical education and research
Year 2018
300 ## - PHYSICAL DESCRIPTION
Pagination 293-304p.
520 ## - SUMMARY, ETC.
Summary, etc. A reversed- phase high-performance liquid chromatographic (RP-HPLC) method based on ion pair formation is demonstrated for the simultaneous determination of Metaxalone (MTX) and Diclofenac potassium (DCP) in commercial formulations. MTX (pKa=12.24) and DCP (pKa=4.00) are hydrophilic ionic substances that make the separation critical due to distinct pKa values. Addition of ionic additives (ion-pairing reagents or chaotropic agents) to the mobile phase allowed a significant improvement in retention of the ionic analytes. However, finding the suitable condition of the Ion-Pair Chromatography(IPC) to achieve desirable separation was challenging and often rebellious to influential chromatographic parameters. The judicious selection of eluent pH, flow rate, acidic modifiers and organic modifier, detector wavelength was performed with the aid of Plackett–Burman design and Box–Behnken design. Desired separation of MTX and DCP was achieved using an Inertsil ODS2 (250x4.6mm; 5μm) column equilibrated with 10mM phosphatebuffer (pH-5.0): acetonitrile (42: 58%v/v) containing0.4%triethylamine and 0.5% tetrabutyl ammonium hydroxideas an eluent at a flow rate of 1.20 mL/min. Under optimal condition, the detection limits are 0.306μg/mL and 0.807μg/mL and limits of quantification 0.927μg/mL and 2.44μg/mL for MTX and DCP respectively. Subsequently, the plausible retention behavior of both analytes was predicted in the ion interaction condition.
650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM
9 (RLIN) 4639
Topical term or geographic name entry element PHARMACEUTICS
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 10141
Co-Author Panda, Jagadeesh
773 0# - HOST ITEM ENTRY
International Standard Serial Number 0019-5464
Title Indian journal of pharmaceutical education and research
Place, publisher, and date of publication Bengluru Association of Pharmaceutical Teachers of India (APTI)
856 ## - ELECTRONIC LOCATION AND ACCESS
URL https://www.ijper.org/sites/default/files/IndJPhaEdRes_52_2_293.pdf
Link text Click here
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme
Koha item type Articles Abstract Database
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          School of Pharmacy School of Pharmacy Archieval Section 2019-10-25 2020016 2019-10-25 2019-10-25 Articles Abstract Database
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