Cytotoxicity Studies of the Chemical Constituents from Marine Algae Chara baltica
By: Tatipamula, V. B
.
Contributor(s): Killari, K. N.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2019Edition: Vol. 81 (05).Description: 815-823p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: For the first time, 89 chemical constituents were identified by gas chromatography-mass spectrometry analysis of ethanol extract of Clathria baltica. The chemical examination of ethanol extract of Clathria baltica yielded three known metabolites, 1, 2 and 3, for first time from the marine algae Clathria baltica. All three metabolites and the ethanol extract of Clathria baltica were screened against cancer cell lines, MCF-7, DLD-1, HeLa, FADU, A549, and SKOV3, and one normal human cell line using sulforhodamine B assay and doxorubicin as the standard. Among all isolates, compound 3 showed significant growth inhibition of MCF-7, DLD-1 and FADU with IC50 values of 26.5, 15.5 and 16.5 µg/ml, respectively. Whereas, all the metabolites and the extract exerted lower growth inhibitory effect on the normal human cell line tested. This is the first in vitro gas chromatography-mass spectrometry analysis, as well as, cytotoxicity report on marine algae Clathria baltica.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020559 |
For the first time, 89 chemical constituents were identified by gas chromatography-mass spectrometry analysis of ethanol extract of Clathria baltica. The chemical examination of ethanol extract of Clathria baltica yielded three known metabolites, 1, 2 and 3, for first time from the marine algae Clathria baltica. All three metabolites and the ethanol extract of Clathria baltica were screened against cancer cell lines, MCF-7, DLD-1, HeLa, FADU, A549, and SKOV3, and one normal human cell line using sulforhodamine B assay and doxorubicin as the standard. Among all isolates, compound 3 showed significant growth inhibition of MCF-7, DLD-1 and FADU with IC50 values of 26.5, 15.5 and 16.5 µg/ml, respectively. Whereas, all the metabolites and the extract exerted lower growth inhibitory effect on the normal human cell line tested. This is the first in vitro gas chromatography-mass spectrometry analysis, as well as, cytotoxicity report on marine algae Clathria baltica.
Click on an image to view it in the image viewer
There are no comments for this item.