Synthesis and antimicrobial evaluation of 3,4-dihydropyrimidin-2(1H)-on analogs
By: Darekar, M
.
Contributor(s): Mehendale, M. S.
Publisher: Mumbai Indian Drug Manufacture's Association - IDMA 2019Edition: Vol.56(5), May.Description: 59-63p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian drugsSummary: This paper reports synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via a three component condensation reaction. The synthesized molecules were tested against bacterial strains Bacillus subtilis and Escherechia coli and against fungal strains Candida albicans and Aspergillus niger.Compounds 4d, 4h, 4l, 4p were found to exhibit very moderate antibacterial activity while compounds 4d, 4l showed very moderate antifungal activity as compared to standards ciprofloxacin and fluconazole
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2020654 |
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This paper reports synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) via a three component condensation reaction. The synthesized molecules were tested against bacterial strains Bacillus subtilis and Escherechia coli and against fungal strains Candida albicans and Aspergillus niger.Compounds 4d, 4h, 4l, 4p were found to exhibit very moderate antibacterial activity while compounds 4d, 4l showed very moderate antifungal activity as compared to standards ciprofloxacin and fluconazole
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