Too much cholesterol can build up in your blood vessels. This build-up can narrow vessels and lead to a blockage, preventing blood from getting to certain parts of your body. When this happens in your heart vessels, it is called coronary heart disease and can cause a heart attack. In people with chronic kidney disease (CKD), heart disease is very common, and is the number one cause of death in this group. It is suggested that people with CKD have their cholesterol tested every year. Your doctor may want to do them more often if something has changed with your health. Most people have high levels of fat in their blood because they eat too much high-fat food. Some people have high fat levels because they have an inherited disorder. High lipid levels may also be caused by medical conditions such as diabetes, hypothyroidism, alcoholism, kidney disease, liver disease and stress. In some people, certain medicines, such as birth control pills, steroids and blood pressure medicines, can cause high lipid levels. Normally in human body lipids are used to synthesize cell walls and hormones but if they get excess in serum can cause illnesses. Dyslipidemia is considered as independent risk for coronary artery disease (CAD). Hypolipidemic agents can prevent hyperlipidemic patients to be sufferer of coronary artery disease. This study was conducted to compare hypolipidemic effects of Niacin and indian fruit (Jujube) in primary as well as secondary hyperlipidemic patients. Study was conducted from June to September 2019 at Jinnah Hospital Lahore, Pakistan. Sixty participants were enrolled of both gender male and female hyperlipidemic patients age range from 20 to 70 years. Written and explained consent was taken from all patients. They were divided in two groups. Group-I was advised to take two grams Niacin in divided doses for the period of two months. Group-II was advised to take 500 grams of fruit Jujube daily for the period of two months. Their baseline LDL and HDL cholesterol was determined by conventional method of measuring Lipid Profile. After two months therapy, their post treatment lipid profile was measured and mean values with±SEM were analyzed biostatistically. Group-I which was on Niacin their LDL cholesterol decreased significantly and HDL cholesterol was increased significantly. In group-II patients LDL cholesterol was decreased significantly but HDL increase was not significant with p-value of >0.05. It was concluded from the research work that Niacin is potent in lowering LDL and increasing HDL cholesterol, while Jujube has significant effect as LDL cholesterol lowering agent, but it does not increase HDL cholesterol significantly.