Synthesis of 1,3,4-oxadiazole and imidazo[1,2-a]pyridine based molecular hybrids and their in vitro antituberculosis and cytotoxicity studies
By: Maurya, Shiv Shyam
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Contributor(s): Gosain, Tannu Priya.
Publisher: New Delhi CSIR 2019Edition: Vol.58B(9), Sep.Description: 1005-1018p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here
In:
Indian journal of chemistry (Section B)Summary: A library of novel 1,3,4-oxadiazole substituted imidazo[1,2-a]pyridine based molecular hybrids have been synthesized and evaluated against Mycobacterium tuberculosis H37Rv. Out of 59 compounds synthesized, ten compounds show activity in the range of 3.125-12.5 M. Compound 8p is found to be most active with MIC99 value of 3.125-6.25 M. Further, these ten compounds have also been tested for their toxicity against THP-1 cell line and are found to be non-toxic with TC50 value in the range of (10 - >50 M) concentration.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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School of Pharmacy Archieval Section | Not for loan | 2020682 |
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A library of novel 1,3,4-oxadiazole substituted imidazo[1,2-a]pyridine based molecular hybrids have been synthesized and evaluated against Mycobacterium tuberculosis H37Rv. Out of 59 compounds synthesized, ten compounds show activity in the range of 3.125-12.5 M. Compound 8p is found to be most active with MIC99 value of 3.125-6.25 M. Further, these ten compounds have also been tested for their toxicity against THP-1 cell line and are found to be non-toxic with TC50 value in the range of (10 - >50 M) concentration.
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