Conventional and microwave-assisted synthesis of coumarin-3-yl-2-oxoethyl carbamodithioates and their DNA cleavage studies
By: Mahesh Kumar, K
.
Contributor(s): Shirahatti, Arunkumar M.
Publisher: New Delhi CSIR 2019Edition: Vol.58B(11), Nov.Description: 1245-1251p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here
In:
Indian journal of chemistry (Section B)Summary: In situ one pot synthesis of coumarin based dithiocarbamates have been studied under conventional and microwave methods. Syntheses of coumarin based dithiocarbamates have been optimized using NaOH, K3PO4 as a base in conventional method whereas K3PO4 has given good yields in less time. The syntheses of dithiocarbamates have been carried out under microwave conditions using K3PO4 as base. The generality of microwave method has been demonstrated by synthesizing a variety of substituents in excellent yields, having short reaction time with good purity compared to those under classical conditions. All the products have been characterized by their IR, GC-MS, 1H and 13C NMR spectral data. Except 2h, 2k, 2l, all these compounds have complete DNA cleavage activity
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2020810 |
In situ one pot synthesis of coumarin based dithiocarbamates have been studied under conventional and microwave methods. Syntheses of coumarin based dithiocarbamates have been optimized using NaOH, K3PO4 as a base in conventional method whereas K3PO4 has given good yields in less time. The syntheses of dithiocarbamates have been carried out under microwave conditions using K3PO4 as base. The generality of microwave method has been demonstrated by synthesizing a variety of substituents in excellent yields, having short reaction time with good purity compared to those under classical conditions. All the products have been characterized by their IR, GC-MS, 1H and 13C NMR spectral data. Except 2h, 2k, 2l, all these compounds have complete DNA cleavage activity
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