Antiangiogenic activity of sophorolipids extracted from refined bleached deodorized palm olein
By: Shazmin Kithur Mohamed
.
Contributor(s): Mohammad Asif.
Publisher: Mumbai Wolter Kluwer 2019Edition: Vol.51(1), Jan-Feb.Description: 45-54p.Subject(s): PHARMACOLOGYOnline resources: Click here
In:
Indian Journal of PharmacologySummary: OBJECTIVES: Sophorolipids(SLs) are a group of surface‑active glycolipids produced by a type of nonpathogenic yeast Candidabombicola in the presence of vegetable oil through fermentation technology. SLs have shown antitumor activity; however, the mechanism of action underlying the anticancer activity of SLs is poorly understood. This work evaluated the anticancer activity of SLs fermented from palm oil by exploring its antiangiogenic activity.MATERIALS AND METHODS: The SLs that were fermented and further characterized for their biochemical activities. Cytotoxicity study was performed to assess cytostatic properties. Aseries of invitro and exvivo angiogenesis assay was also carried out. The relative fold change in the expression of p53 mRNA by SLs was also studied.RESULTS: Altogether, the data show that SLs derived from palm oil fermentation process inhibited neovascularization in the exvivo tissue segments and also the endothelial cell proliferation between 50% and 65% inhibition as a whole. The palm oil derived SLs also caused downregulation of the suppression level of vascular endothelial growth factor and also upregulate the p53 mRNA level. The analytical studies revealed the presence of high amount of phenolic compounds but with relatively weak antioxidant activity. The gas chromatography‑mass spectrometry studies revealed abundant amount of palmitic and oleic acid, the latter an established antiangiogenic agent, and the former being proangiogenic.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2020844 |
OBJECTIVES: Sophorolipids(SLs) are a group of surface‑active glycolipids produced by a type of nonpathogenic yeast Candidabombicola in the presence of vegetable oil through fermentation technology. SLs have shown antitumor activity; however, the mechanism of action underlying the anticancer activity of SLs is poorly understood. This work evaluated the anticancer activity of SLs fermented from palm oil by exploring its antiangiogenic activity.MATERIALS AND METHODS: The SLs that were fermented and further characterized for their biochemical activities. Cytotoxicity study was performed to assess cytostatic properties. Aseries of invitro and exvivo angiogenesis assay was also carried out. The relative fold change in the expression of p53 mRNA by SLs was also studied.RESULTS: Altogether, the data show that SLs derived from palm oil fermentation process inhibited neovascularization in the exvivo tissue segments and also the endothelial cell proliferation between 50% and 65% inhibition as a whole. The palm oil derived SLs also caused downregulation of the suppression level of vascular endothelial growth factor and also upregulate the p53 mRNA level. The analytical studies revealed the presence of high amount of phenolic compounds but with relatively weak antioxidant activity. The gas chromatography‑mass spectrometry studies revealed abundant amount of palmitic and oleic acid, the latter an established antiangiogenic agent, and the former being proangiogenic.
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