NANO-SPONGE NOVEL DRUG DELIVERY SYSTEM AS CARRIER O F ANTI-HYPERTENSIVE DRUG
By: Al-Assal, Mona Ibrahim
.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2019Edition: Vol.11(10).Description: 47-63p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective:
The study was designed to prepare Nano-sponge formu
lation loaded with nifedipine. Studying parameters
which affecting the formulas
in addition to pharmacokinetics and toxicity tests.
Methods:
Nine Nano-sponge formulations were prepared by the
solvent evaporation technique. Different ratios of
polymer ethylcellulose, CO-
polymers β-cyclodextrin and hydroxypropyl β-cyclode
xtrin in addition to solubilizing agent polyvinyl a
lcohol were used. Thermal analysis, X-ray
powder diffraction (XRPD), shape and surface morpho
logy, particle size, %production yield, %porosity,
% swelling, and % drug entrapment
efficiency of Nano-sponge were examined. Release ki
netic also studied beside comparison of pharmacokin
etic parameters of the optimum choice
formula and marketed one in addition to Toxicologic
al consideration.
Results:
Particle size in the range of 119.1 nm to 529 nm wh
ich were increased due to the increase in the conce
ntration of polymer to the drug.
Nano-sponge revealed porous, spherical nature. Incr
eased in the drug/polymer molar ratios (1:1 to 1:3)
may increase their % production yield
ranged from 62.1% to 92.4%. The drug content of dif
ferent formulations was in the range of 77.9% to 94
.7%, and entrapment efficiency was in the
range of 82.72 % to 96.63%. Drug released in contro
lled sustained pattern and followed Higuchi, s diff
usion mechanism. Pharmacokinetic
parameters of optimized formula showed significant
higher maximum plasma drug concentration, area unde
r plasma concentration-time curve,
volume of distribution and mean residence time. Nan
o-sponge loaded drug proved biological safety at lo
w concentrations.
Conclusion:
Nano-sponge drug delivery system has showed small N
ano size, porous with controlled drug release and s
ignificant-high plasma drug
concentration that improved solubility, drug bioava
ilability and proved safety.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2020864 |
Objective:
The study was designed to prepare Nano-sponge formu
lation loaded with nifedipine. Studying parameters
which affecting the formulas
in addition to pharmacokinetics and toxicity tests.
Methods:
Nine Nano-sponge formulations were prepared by the
solvent evaporation technique. Different ratios of
polymer ethylcellulose, CO-
polymers β-cyclodextrin and hydroxypropyl β-cyclode
xtrin in addition to solubilizing agent polyvinyl a
lcohol were used. Thermal analysis, X-ray
powder diffraction (XRPD), shape and surface morpho
logy, particle size, %production yield, %porosity,
% swelling, and % drug entrapment
efficiency of Nano-sponge were examined. Release ki
netic also studied beside comparison of pharmacokin
etic parameters of the optimum choice
formula and marketed one in addition to Toxicologic
al consideration.
Results:
Particle size in the range of 119.1 nm to 529 nm wh
ich were increased due to the increase in the conce
ntration of polymer to the drug.
Nano-sponge revealed porous, spherical nature. Incr
eased in the drug/polymer molar ratios (1:1 to 1:3)
may increase their % production yield
ranged from 62.1% to 92.4%. The drug content of dif
ferent formulations was in the range of 77.9% to 94
.7%, and entrapment efficiency was in the
range of 82.72 % to 96.63%. Drug released in contro
lled sustained pattern and followed Higuchi, s diff
usion mechanism. Pharmacokinetic
parameters of optimized formula showed significant
higher maximum plasma drug concentration, area unde
r plasma concentration-time curve,
volume of distribution and mean residence time. Nan
o-sponge loaded drug proved biological safety at lo
w concentrations.
Conclusion:
Nano-sponge drug delivery system has showed small N
ano size, porous with controlled drug release and s
ignificant-high plasma drug
concentration that improved solubility, drug bioava
ilability and proved safety.
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