Biosynthesis of Silver Nanoparticles using Annona squamosa Leaf Extract with Synergistic Antibacterial Activity
By: Kalyani, R. Lakshmi
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Contributor(s): Chandra, V. S.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2019Edition: Vol.81(6), Nov-Dec.Description: 1036-1044p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: In the era of increased prevalence of bacterial resistance and outbreak of resistant infectious diseases, it is essential to develop effective therapeutic strategies towards multi-drug resistant pathogens. In this scenario, silver nanoparticles were tailored using Annona squamosaleaf extract and evaluated using various characterization techniques such as high-performance thin-layer chromatography, UV/Vis, scanning electron microscopy, X-ray powder diffraction, and Fourier-transform infrared spectroscopy. The synthesized AgNPs were assessed for antibacterial activity towards various Gram-positive and Gram-negative bacteria. In addition, the pharmacodynamic interaction of green synthesized AgNPs was assessed with gentamicin towards various bacteria as a novel adjuvant protocol, which revealed the remarkable antibacterial effect in comparison with AgNPs, or gentamicin alone. The superior biological activity was attributed to metabolites in plant extract, synthetic strategy of ultra-small AgNPs and synergistic effect of nano antibiotics
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2020-2021148 |
In the era of increased prevalence of bacterial resistance and outbreak of resistant infectious diseases, it is essential to develop effective therapeutic strategies towards multi-drug resistant pathogens. In this scenario, silver nanoparticles were tailored using Annona squamosaleaf extract and evaluated using various characterization techniques such as high-performance thin-layer chromatography, UV/Vis, scanning electron microscopy, X-ray powder diffraction, and Fourier-transform infrared spectroscopy. The synthesized AgNPs were assessed for antibacterial activity towards various Gram-positive and Gram-negative bacteria. In addition, the pharmacodynamic interaction of green synthesized AgNPs was assessed with gentamicin towards various bacteria as a novel adjuvant protocol, which revealed the remarkable antibacterial effect in comparison with AgNPs, or gentamicin alone. The superior biological activity was attributed to metabolites in plant extract, synthetic strategy of ultra-small AgNPs and synergistic effect of nano antibiotics
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