Development of pH-Responsive Interpenetrating Polymer Networks of Polyacrylamide-g-Gum Arabica and Sodium Alginate for Gastroprotective Delivery of Gabapentin
By: PRAMANIK, S
.
Contributor(s): DUTTA, J.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(3), May-June.Description: 473-482p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: In the present work, a grafted polymer of polyacrylamide with gum arabica was synthesized as Gum
acacia-g-polyacrylamide using microwave-assisted synthesis with ceric ammonium nitrate as a reaction
initiator. The polymer was utilized in combination with sodium alginate to prepare interpenetrating
polymer network hydrogel beads to effectively deliver gabapentin in gastrointestinal tract. The formulated
interpenetrating polymer network microbeads showed pH-responsive release in a different medium. The
interpenetrating polymer network hydrogel beads were processed for different analytical characterization
like Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray powder diffraction
and scanning electron microscopy. The Fourier transform infrared spectroscopy study confirms the
formation of gum acacia-g-polyacrylamide whereas differential scanning calorimetry, X-ray powder
diffraction studies confirm the appearance of gabapentin in the interpenetrating polymer network micro-
bead formulations. The release of the drug from the interpenetrating polymer network structured hydrogel
beads was found higher in pH 6.8 as compared to pH 1.2 and pH 7.4 indicating the effective delivery of
gabapentin from the interpenetrating polymer network beads to upper duodenum for better absorption.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2021-2022555 |
In the present work, a grafted polymer of polyacrylamide with gum arabica was synthesized as Gum
acacia-g-polyacrylamide using microwave-assisted synthesis with ceric ammonium nitrate as a reaction
initiator. The polymer was utilized in combination with sodium alginate to prepare interpenetrating
polymer network hydrogel beads to effectively deliver gabapentin in gastrointestinal tract. The formulated
interpenetrating polymer network microbeads showed pH-responsive release in a different medium. The
interpenetrating polymer network hydrogel beads were processed for different analytical characterization
like Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray powder diffraction
and scanning electron microscopy. The Fourier transform infrared spectroscopy study confirms the
formation of gum acacia-g-polyacrylamide whereas differential scanning calorimetry, X-ray powder
diffraction studies confirm the appearance of gabapentin in the interpenetrating polymer network micro-
bead formulations. The release of the drug from the interpenetrating polymer network structured hydrogel
beads was found higher in pH 6.8 as compared to pH 1.2 and pH 7.4 indicating the effective delivery of
gabapentin from the interpenetrating polymer network beads to upper duodenum for better absorption.
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