Brain Training Improves Cigarette Smoke Induced Dementia in Female C57 Black 6 Mice
By: ANJALI RAJ
.
Contributor(s): MADHUNAPATULA, S. V.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(3), May-June.Description: 483-493p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Alzheimer’s disease is a chronic neurodegenerative disease among the elderly population. Various genetic,
environmental and lifestyle factors have been associated with the etiology of Alzheimer’s disease. Cigarette
smoke has been reported to be a major predisposing factor for Alzheimer’s disease and contributes to
disease development. Conversely, studies have reported beneficial effects of brain training on the disease
condition. The purpose of this study was to evaluate the effect of a brain training task in cigarette smoke
induced dementia. Three groups of female C57 black 6 mice were used in the study with two of the groups
subjected to cigarette smoke exposure. The third group was subjected to a novel object test immediately after
the exposure. Brain training improved the cognitive domains of the smoke exposed mice. Brain training
could also regain the neurotransmitter imbalances induced by cigarette smoke, importantly, decreased the
glutamate levels in the hippocampus. Brain training also significantly decreased the hippocampal amyloid
precursor protein expression levels by reducing the reactive oxygen species production. Additionally, the
improved hippocampal neuronal count, post training supported the findings. The results indicated that
brain training significantly decreased the deleterious effects of cigarette smoke in hippocampus tissue and
improved dementia symptoms
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2021-2022556 |
Alzheimer’s disease is a chronic neurodegenerative disease among the elderly population. Various genetic,
environmental and lifestyle factors have been associated with the etiology of Alzheimer’s disease. Cigarette
smoke has been reported to be a major predisposing factor for Alzheimer’s disease and contributes to
disease development. Conversely, studies have reported beneficial effects of brain training on the disease
condition. The purpose of this study was to evaluate the effect of a brain training task in cigarette smoke
induced dementia. Three groups of female C57 black 6 mice were used in the study with two of the groups
subjected to cigarette smoke exposure. The third group was subjected to a novel object test immediately after
the exposure. Brain training improved the cognitive domains of the smoke exposed mice. Brain training
could also regain the neurotransmitter imbalances induced by cigarette smoke, importantly, decreased the
glutamate levels in the hippocampus. Brain training also significantly decreased the hippocampal amyloid
precursor protein expression levels by reducing the reactive oxygen species production. Additionally, the
improved hippocampal neuronal count, post training supported the findings. The results indicated that
brain training significantly decreased the deleterious effects of cigarette smoke in hippocampus tissue and
improved dementia symptoms
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