Effect of Azalea on Oxidative Stress, Immune Factors and Vasodilator Factor in Hypertensive Rats
By: LIU, Z
.
Contributor(s): GUO, JING.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(3), May-June.Description: 535-540p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: To analyze the effects of azalea on oxidative stress, immune factors and vasodilator factors in hypertensive
rats. 24 male Specific-pathogen-free grade spontaneous hypertension rats were divided into model group
(normal saline), azalea group (50 mg/kg/d azalea), verapamil group (50 mg/kg/d verapamil) and 8 normal
control group (normal saline) and observed the changes of tail artery systolic pressure of rats for 2-18
w after administration, superoxide dismutase, malondialdehyde were detected after 18 w The levels of
nuclear factor kappa B, Smooth muscle alpha-actin and Smooth muscle alpha actin were detected by
reverse transcription–polymerase chain reaction and Western blot. The systolic pressure of the caudal
artery in azalea group and verapamil group was significantly lower than that in the model group (p<0.05).
The levels of Malondialdehyde and reactive oxygen species in azalea group and verapamil group were
significantly lower than that in the model group and Superoxide dismutase level was significantly higher
than that in the model group (p<0.05). The levels of interleukin-6 and tumor necrosis factor-alpha in
azalea group and verapamil group were significantly lower than those in the model group (p<0.05). The
levels of Angiotensin α and endothelin-1 in azalea group and verapamil group were significantly lower
than that in the model group and no and nitric oxide synthase levels were significantly higher than those
in the model group (p<0.05). The expression of nuclear factor kappa light chain enhancer of activated B
cells messenger Ribonucleic acid and protein in azalea group and verapamil group was significantly lower
than that in model group and Smooth muscle alpha-actin messenger Ribonucleic acid and protein were
significantly higher than that in model group (p<0.05). Azalea can significantly reduce the systolic pressure
of hypertensive rats and protect the aortic injury. It may be related to the reduction of oxidative stress,
regulation of immune factors and diastolic vasodilator factors, and regulation of nuclear factor kappa light
chain enhancer of activated B cells, Smooth muscle alpha-actin expressions
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2021-2022562 |
To analyze the effects of azalea on oxidative stress, immune factors and vasodilator factors in hypertensive
rats. 24 male Specific-pathogen-free grade spontaneous hypertension rats were divided into model group
(normal saline), azalea group (50 mg/kg/d azalea), verapamil group (50 mg/kg/d verapamil) and 8 normal
control group (normal saline) and observed the changes of tail artery systolic pressure of rats for 2-18
w after administration, superoxide dismutase, malondialdehyde were detected after 18 w The levels of
nuclear factor kappa B, Smooth muscle alpha-actin and Smooth muscle alpha actin were detected by
reverse transcription–polymerase chain reaction and Western blot. The systolic pressure of the caudal
artery in azalea group and verapamil group was significantly lower than that in the model group (p<0.05).
The levels of Malondialdehyde and reactive oxygen species in azalea group and verapamil group were
significantly lower than that in the model group and Superoxide dismutase level was significantly higher
than that in the model group (p<0.05). The levels of interleukin-6 and tumor necrosis factor-alpha in
azalea group and verapamil group were significantly lower than those in the model group (p<0.05). The
levels of Angiotensin α and endothelin-1 in azalea group and verapamil group were significantly lower
than that in the model group and no and nitric oxide synthase levels were significantly higher than those
in the model group (p<0.05). The expression of nuclear factor kappa light chain enhancer of activated B
cells messenger Ribonucleic acid and protein in azalea group and verapamil group was significantly lower
than that in model group and Smooth muscle alpha-actin messenger Ribonucleic acid and protein were
significantly higher than that in model group (p<0.05). Azalea can significantly reduce the systolic pressure
of hypertensive rats and protect the aortic injury. It may be related to the reduction of oxidative stress,
regulation of immune factors and diastolic vasodilator factors, and regulation of nuclear factor kappa light
chain enhancer of activated B cells, Smooth muscle alpha-actin expressions
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