Application of Box-Behnken Design for Formulation Parameters of Eslicarbazepine Tablets
By: Paravastu, Venkata Kamala Kumari
.
Contributor(s): YARRAGUNTLA, S. R.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(3), May-June.Description: 575-583p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Current research has been done to develop statistically and optimized immediate release tablets for
eslicarbazepine. Nineteen formulations of eslicarbazepine acetate immediate release tablets are prepared
by wet granulation. The three-dimensional Box-Behnken design at three levels (33) was developed to study
how selected independent variables affect dependent responses. After the initial test, three independent
items were selected as follows; polyvinylpyrrolidone (A), tapioca starch (B) and galbanum gum (C).
Responses to measure were the time of disintegration (Y1) and in vitro drug release at 45 min (Y2). In
accordance with the independent variables, three different levels were established as the lowest, highest
and middle variables tested. The predicted formula formulated with the Box-Behnken statistical design
consisted of polyvinylpyrrolidone, tapioca starch and galbanum gum at the optimum levels of 2.49, 2.77
and 3 respectively.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2021-2022570 |
Current research has been done to develop statistically and optimized immediate release tablets for
eslicarbazepine. Nineteen formulations of eslicarbazepine acetate immediate release tablets are prepared
by wet granulation. The three-dimensional Box-Behnken design at three levels (33) was developed to study
how selected independent variables affect dependent responses. After the initial test, three independent
items were selected as follows; polyvinylpyrrolidone (A), tapioca starch (B) and galbanum gum (C).
Responses to measure were the time of disintegration (Y1) and in vitro drug release at 45 min (Y2). In
accordance with the independent variables, three different levels were established as the lowest, highest
and middle variables tested. The predicted formula formulated with the Box-Behnken statistical design
consisted of polyvinylpyrrolidone, tapioca starch and galbanum gum at the optimum levels of 2.49, 2.77
and 3 respectively.
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