Pyridine Moiety: Recent Advances in Cancer Treatment
By: SAHU, R
.
Contributor(s): MISHRA, R.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(2), March-April.Description: 162-185p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Pyridine is an imperative pharmacophore, a privileged scaffold and an exceptional heterocyclic system in
the field of drug discovery which provides many opportunities in study/explore this moiety as an anticancer
agent by acting on various receptors of utmost importance. Several pyridine derivatives are reported to
inhibit tubulin polymerization, androgen receptors, human carbonic anhydrase, kinase, topoisomerase
enzyme and many other targets for controlling and curing global health issue of cancer. Now a days in
combination with other moieties researchers are focusing for development of pyridine new entities for
the treatment of cancer. This review throws light on recent biological expansions of pyridine along with
their structure activity relationships/molecular docking to deliver association between various synthesized
newer derivatives and receptor sites.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2021-2022577 |
Pyridine is an imperative pharmacophore, a privileged scaffold and an exceptional heterocyclic system in
the field of drug discovery which provides many opportunities in study/explore this moiety as an anticancer
agent by acting on various receptors of utmost importance. Several pyridine derivatives are reported to
inhibit tubulin polymerization, androgen receptors, human carbonic anhydrase, kinase, topoisomerase
enzyme and many other targets for controlling and curing global health issue of cancer. Now a days in
combination with other moieties researchers are focusing for development of pyridine new entities for
the treatment of cancer. This review throws light on recent biological expansions of pyridine along with
their structure activity relationships/molecular docking to deliver association between various synthesized
newer derivatives and receptor sites.
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