Standardized Extract (HemoHIM) from Angelica gigas Nakai, Cnidium officinale Makino and Paeonia lactiflora Pallas Extract Attenuates Acetaminophen-Induced Liver Injury in Human Hepatocellular Carcinoma Cells and Mice Model
By: KWON, DA AE
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Contributor(s): KIM, Y. S.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(2), March-April.Description: 195-203p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: In this study, the hepatoprotective e ffects of the herbal preparation (HemoHIM) against acetaminophen-
induced liver injury were investigated in vitro and in vivo. We investigated the messenger Ribonucleic acid
expression of antioxidant factors and proinflammatory cytokines in human hepatocellular carcinoma cells
treated with acetaminophen. In vivo study, Institute of Cancer Research mice was divided intofive groups
(n=10): control, acetaminophen, HemoHIM 250, 500 mg/kg body weight and silymarin 200 mg/kg body
weight, respectively. Mice were administrated acetaminophen (350 mg/kg body weight) on d 5 after sample
administration. Blood samples were collected for aspartate aminotransferase, alanine transaminase
assessment. Liver tissue was determined for glutathione, triglyceride, cholesterol and histopathological
features. HemoHIM has significant effects in the treatment groups compared to acetaminophen group.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2021-2022579 |
In this study, the hepatoprotective e ffects of the herbal preparation (HemoHIM) against acetaminophen-
induced liver injury were investigated in vitro and in vivo. We investigated the messenger Ribonucleic acid
expression of antioxidant factors and proinflammatory cytokines in human hepatocellular carcinoma cells
treated with acetaminophen. In vivo study, Institute of Cancer Research mice was divided intofive groups
(n=10): control, acetaminophen, HemoHIM 250, 500 mg/kg body weight and silymarin 200 mg/kg body
weight, respectively. Mice were administrated acetaminophen (350 mg/kg body weight) on d 5 after sample
administration. Blood samples were collected for aspartate aminotransferase, alanine transaminase
assessment. Liver tissue was determined for glutathione, triglyceride, cholesterol and histopathological
features. HemoHIM has significant effects in the treatment groups compared to acetaminophen group.
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