Protective Effects of Smilax glabra Roxb on Carbon Tetrachloride Induced Rat Acute Liver Injury by Inhibiting the Activation of the Nucleotide-Binding Domain Leucine-Rich Repeat Containing Pyrin Domain containing 3 Inflammasome
By: HAN, C. Y
.
Contributor(s): KANG, Y. X.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(2), March-April.Description: 278-286p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: The experiment was conducted to investigate the protective effect of Smilax glabra Roxb. aqueous extract
on carbon tetrachloride induced acute liver injury in rats by regulating the nucleotide binding leucine
rich repeat receptors family pyrin domain containing 3 in flammasome. In this study, a rat acute liver
injury model was established by a single intraperitoneal injection of 50 % carbon tetrachloride oil solution
(1 ml/kg body weight). A total of 50 rats were randomly divided into control group, model group and
3 Smilax glabra Roxb. aqueous extract intervention groups (0.75, 1.5 and 3 g/kg body weight/d). Smilax
glabra Roxb. aqueous extract or distilled water was orally administered by gavage once daily for seven
consecutive days. Then the blood and liver samples were collected. The results showed that in the
3 intervention Smilax glabra Roxb. aqueous extract groups, the levels of serum aspartate aminotransferase
and Alanine aminotransferase, the content of malondialdehyde in rat liver tissues signi ficantly reduced
and superoxide dismutase, catalase and glutathione increased signi ficantly, the liver lobule structures
were repaired and the liver cells were aligned in an orderly manner, the expressions of nucleotide binding
leucine rich repeat receptors family pyrin domain containing 3 in flammasome, apoptosis associated
speck like protein containing and caspase-1 proteins, Interleukin 1 beta messenger ribonucleic acid was
decreased. Smilax glabra Roxb. aqueous extract exerted a protective e ffect against carbon tetrachloride
induced acute liver injury by inhibiting the activation of nucleotide binding leucine rich repeat receptors
family pyrin domain containing 3 inflammasome, which suggest a promising avenue for the exploration of
Smilax glabra Roxb. aqueous extract in improving acute liver injury
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2021-2022598 |
The experiment was conducted to investigate the protective effect of Smilax glabra Roxb. aqueous extract
on carbon tetrachloride induced acute liver injury in rats by regulating the nucleotide binding leucine
rich repeat receptors family pyrin domain containing 3 in flammasome. In this study, a rat acute liver
injury model was established by a single intraperitoneal injection of 50 % carbon tetrachloride oil solution
(1 ml/kg body weight). A total of 50 rats were randomly divided into control group, model group and
3 Smilax glabra Roxb. aqueous extract intervention groups (0.75, 1.5 and 3 g/kg body weight/d). Smilax
glabra Roxb. aqueous extract or distilled water was orally administered by gavage once daily for seven
consecutive days. Then the blood and liver samples were collected. The results showed that in the
3 intervention Smilax glabra Roxb. aqueous extract groups, the levels of serum aspartate aminotransferase
and Alanine aminotransferase, the content of malondialdehyde in rat liver tissues signi ficantly reduced
and superoxide dismutase, catalase and glutathione increased signi ficantly, the liver lobule structures
were repaired and the liver cells were aligned in an orderly manner, the expressions of nucleotide binding
leucine rich repeat receptors family pyrin domain containing 3 in flammasome, apoptosis associated
speck like protein containing and caspase-1 proteins, Interleukin 1 beta messenger ribonucleic acid was
decreased. Smilax glabra Roxb. aqueous extract exerted a protective e ffect against carbon tetrachloride
induced acute liver injury by inhibiting the activation of nucleotide binding leucine rich repeat receptors
family pyrin domain containing 3 inflammasome, which suggest a promising avenue for the exploration of
Smilax glabra Roxb. aqueous extract in improving acute liver injury
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