Simultaneous estimation of solifenacin succinate and tamsulosin hydrochloride in combined dosage form by using first order derivative spectrophotometric method
By: Yarraguntla, S. R
.
Contributor(s): Kumar, T. H.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(2), March-April.Description: 331-335p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Using first-order derivative techniques, a simple accurate and precise Ultraviolet spectrophotometric
method was developed for the determination of solifenacin succinate and tamsulosin hydrochloride in
combined dosage form. Every soli finacin succinate and tamsulosin hydrochloride was scanned in the
wavelength region of 200-400 nm for determination of sampling wavelengths and selected sampling
wavelengths were selected. Sampling wavelengths were chosen at 265 nm (zero crossing of soli finacin
succinate) where the absorbance of tamsulosin hydrochloride was important and at 250 nm (zero crossing
of tamsulosin hydrochloride) where the absorbance of solifinacin succinate was significant. For solifenacin
succinate, linearity ranged from 10 to 100 μg/ml with a correlation coe fficient of 0.998 and 2 to 10 μg/ml
for the correlation coefficient of tamsulosin hydrochloride is 0.9988. The median recovery was considered
to be satisfactory. For the routine study of solifenacin succinate and tamsulosin hydrochloride in combined
dosage forms, the approach proposed can be applie.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2021-2022606 |
Using first-order derivative techniques, a simple accurate and precise Ultraviolet spectrophotometric
method was developed for the determination of solifenacin succinate and tamsulosin hydrochloride in
combined dosage form. Every soli finacin succinate and tamsulosin hydrochloride was scanned in the
wavelength region of 200-400 nm for determination of sampling wavelengths and selected sampling
wavelengths were selected. Sampling wavelengths were chosen at 265 nm (zero crossing of soli finacin
succinate) where the absorbance of tamsulosin hydrochloride was important and at 250 nm (zero crossing
of tamsulosin hydrochloride) where the absorbance of solifinacin succinate was significant. For solifenacin
succinate, linearity ranged from 10 to 100 μg/ml with a correlation coe fficient of 0.998 and 2 to 10 μg/ml
for the correlation coefficient of tamsulosin hydrochloride is 0.9988. The median recovery was considered
to be satisfactory. For the routine study of solifenacin succinate and tamsulosin hydrochloride in combined
dosage forms, the approach proposed can be applie.
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