Protective mechanism of xiyin liangxue decoction on immunoglobulin a nephropathy rats
By: Wei, Jing
.
Contributor(s): Li, Ming.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(2), March-April.Description: 371-379p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Immunoglobulin A nephropathy is the most common glomerular disease in China, accounting for about
20 % to 47 % of primary glomerular diseases. Xiyin liangxue decoction is a common experience in the
treatment of immunoglobulin A nephropathy in recent years. The research of this formula in the clinical
treatment of immunoglobulin A nephropathy has achieved obvious curative e ffect. This article aims to
study the protective mechanism of xiyin liangxue decoction on immunoglobulin A nephropathy rats and
analyzes and compares the advantages of xiyin liangxue decoction and western medicine in the treatment
of immunoglobulin A nephropathy rats with Sprague dawley nephropathy rats. The results of the study
showed that after treatment of immunoglobulin A nephropathy rats with xiyin liangxue decoction, the
renal function of the rats in the treatment group was signi ficantly improved, the expressions of alanine
aminotransferase and aspartate aminotransferase increased by 19 % and 5 % and the expressions of
albumin and globulin increased by 19 % and 25 %. In addition, in the treatment group, the number
of urine red blood cells, urine protein and urine mannose binding lectin decreased by 29 %, 13 % and
25 %, respectively. The urine volume of rats in the high dose group was significantly reduced by 13 % and
the expressions of blood urea nitrogen and blood creatinine increased 22 % and 8 % respectively. After
treatment with xiyin liangxue decoction, the cure rate of experimental immunoglobulin A rats reached
24 % and 33 % had signi ficant improvement. It can be seen that xiyin liangxue decoction has a good
clinical treatment effect on immunoglobulin A nephropathy rats.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2021-2022613 |
Immunoglobulin A nephropathy is the most common glomerular disease in China, accounting for about
20 % to 47 % of primary glomerular diseases. Xiyin liangxue decoction is a common experience in the
treatment of immunoglobulin A nephropathy in recent years. The research of this formula in the clinical
treatment of immunoglobulin A nephropathy has achieved obvious curative e ffect. This article aims to
study the protective mechanism of xiyin liangxue decoction on immunoglobulin A nephropathy rats and
analyzes and compares the advantages of xiyin liangxue decoction and western medicine in the treatment
of immunoglobulin A nephropathy rats with Sprague dawley nephropathy rats. The results of the study
showed that after treatment of immunoglobulin A nephropathy rats with xiyin liangxue decoction, the
renal function of the rats in the treatment group was signi ficantly improved, the expressions of alanine
aminotransferase and aspartate aminotransferase increased by 19 % and 5 % and the expressions of
albumin and globulin increased by 19 % and 25 %. In addition, in the treatment group, the number
of urine red blood cells, urine protein and urine mannose binding lectin decreased by 29 %, 13 % and
25 %, respectively. The urine volume of rats in the high dose group was significantly reduced by 13 % and
the expressions of blood urea nitrogen and blood creatinine increased 22 % and 8 % respectively. After
treatment with xiyin liangxue decoction, the cure rate of experimental immunoglobulin A rats reached
24 % and 33 % had signi ficant improvement. It can be seen that xiyin liangxue decoction has a good
clinical treatment effect on immunoglobulin A nephropathy rats.
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