Correlation between serum 25-hydroxyvitamin D3 and abnormal insulin secretion in patients with type 2 diabetes mellitus
By: Hou, Yani
.
Contributor(s): Hu, Xiaojia.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(1), Jan-Feb.Description: 158-161p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: To investigate the correlation between serum 25-hydroxyvitamin D3 and abnormal insulin secretion in
patients with type 2 diabetes mellitus. Eight type 2 diabetes mellitus patients treated from January 2018 to
November 2020 (observation group) and another 80 healthy volunteers receiving physical examination in
the same period (control group) were included. Fasting venous blood sample was collected to detect serum
25-hydroxyvitamin D3, fasting blood glucose, glycosylated hemoglobin, fasting insulin, insulin resistance
index and insulin secretion index. According to insulin secretion index, observation group was divided
into normal and abnormal insulin secretion groups and their serum 25-hydroxyvitamin D3, fasting blood
glucose, glycosylated hemoglobin, fasting insulin and insulin resistance index were compared. Based on
serum 25-hydroxyvitamin D3 level, observation group was divided into serum 25-hydroxyvitamin D3
positive and negative groups and their fasting blood glucose, glycosylated hemoglobin, fasting insulin, insulin
resistance index and insulin secretion index were compared. The correlations of serum 25-hydroxyvitamin
D3 with fasting blood glucose, glycosylated hemoglobin, fasting insulin, insulin resistance index and
insulin secretion index were analyzed. Observation group had lower serum 25-hydroxyvitamin D3 level
and insulin secretion index and higher fasting blood glucose, glycosylated hemoglobin, fasting insulin and insulin resistance index than those of control group (p<0.05). Abnormal insulin secretion group had lower
serum 25-hydroxyvitamin D3 level and higher fasting blood glucose, fasting insulin and insulin resistance
index than those of normal insulin secretion group (p<0.05). Serum 25-hydroxyvitamin D3 positive group
had higher fasting blood glucose, glycosylated hemoglobin, fasting insulin and insulin resistance index and
lower insulin secretion index than those of serum 25-hydroxyvitamin D3 negative group (p<0.05). Serum
25-hydroxyvitamin D3 was negatively correlated with fasting blood glucose, glycosylated hemoglobin,
fasting insulin and insulin resistance index, but positively correlated with insulin secretion index. In type
2 diabetes mellitus patients, the expression of serum 25-hydroxyvitamin D3 is down-regulated, which is
closely related to abnormal insulin secretion. Serum 25-hydroxyvitamin D3 can be used to determine the
insulin secretion function of type 2 diabetes mellitus patients.
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2021-2022640 |
To investigate the correlation between serum 25-hydroxyvitamin D3 and abnormal insulin secretion in
patients with type 2 diabetes mellitus. Eight type 2 diabetes mellitus patients treated from January 2018 to
November 2020 (observation group) and another 80 healthy volunteers receiving physical examination in
the same period (control group) were included. Fasting venous blood sample was collected to detect serum
25-hydroxyvitamin D3, fasting blood glucose, glycosylated hemoglobin, fasting insulin, insulin resistance
index and insulin secretion index. According to insulin secretion index, observation group was divided
into normal and abnormal insulin secretion groups and their serum 25-hydroxyvitamin D3, fasting blood
glucose, glycosylated hemoglobin, fasting insulin and insulin resistance index were compared. Based on
serum 25-hydroxyvitamin D3 level, observation group was divided into serum 25-hydroxyvitamin D3
positive and negative groups and their fasting blood glucose, glycosylated hemoglobin, fasting insulin, insulin
resistance index and insulin secretion index were compared. The correlations of serum 25-hydroxyvitamin
D3 with fasting blood glucose, glycosylated hemoglobin, fasting insulin, insulin resistance index and
insulin secretion index were analyzed. Observation group had lower serum 25-hydroxyvitamin D3 level
and insulin secretion index and higher fasting blood glucose, glycosylated hemoglobin, fasting insulin and insulin resistance index than those of control group (p<0.05). Abnormal insulin secretion group had lower
serum 25-hydroxyvitamin D3 level and higher fasting blood glucose, fasting insulin and insulin resistance
index than those of normal insulin secretion group (p<0.05). Serum 25-hydroxyvitamin D3 positive group
had higher fasting blood glucose, glycosylated hemoglobin, fasting insulin and insulin resistance index and
lower insulin secretion index than those of serum 25-hydroxyvitamin D3 negative group (p<0.05). Serum
25-hydroxyvitamin D3 was negatively correlated with fasting blood glucose, glycosylated hemoglobin,
fasting insulin and insulin resistance index, but positively correlated with insulin secretion index. In type
2 diabetes mellitus patients, the expression of serum 25-hydroxyvitamin D3 is down-regulated, which is
closely related to abnormal insulin secretion. Serum 25-hydroxyvitamin D3 can be used to determine the
insulin secretion function of type 2 diabetes mellitus patients.
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