Chemistry of fluoroquinones in the management of tuberculosis (TB): an overview
By: Jain, Sourabh D
.
Contributor(s): Gupta, Arun Kumar.
Publisher: Raipur Asian Pharma Press 2021Edition: Vol.11(1), Jan-Mar.Description: 55-59p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Asian journal of pharmaceutical researchSummary: Sourabh D Jain*, Arun Kumar Gupta Assistant Professor, Chameli Devi Institute of Pharmacy, Indore (M.P.) India. *Corresponding Author E-mail: sourabhjain072@gmail.com Tuberculosis is a serious global health problem, as one-third of the world’s population is estimated to be infected with Mycobacterium tuberculosis, and eight million new active cases occurred annually. Today, medicine is applied more technically and mechanically and on the other hand, effort is necessary not only for controlling the disease but also for increasing the quality of the life of patients. Quinolone comprise a relatively large, growing and most interesting group of antibacterial drugs which have made a major impact on the field of antimicrobial chemotherapy, particularly in the past few years. This is due to their potentiality offer many of the attributes of an ideal antibiotic, combining high potency, a broad spectrum of activity, good bioavailability, oral and intravenous formulations, high serum levels, a large volume of distribution indicating concentration in tissues and a potentially low incidence of side-effects. More researches have attempted to make these potential attributes continuously in the field of bacterial infections. After reviewing the current position on bacterial as well as tubercle bacillus, attempt was done, based on the above mentioned facts and explore some new derivatives of fluoroquinolone by synthesizing and evaluating the targeted bacterial organisms. So, it is desired the efficacy of new fluoroquinolone derivatives for the treatment of tuberculosis.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-0048 |
Sourabh D Jain*, Arun Kumar Gupta Assistant Professor, Chameli Devi Institute of Pharmacy, Indore (M.P.) India. *Corresponding Author E-mail: sourabhjain072@gmail.com Tuberculosis is a serious global health problem, as one-third of the world’s population is estimated to be infected with Mycobacterium tuberculosis, and eight million new active cases occurred annually. Today, medicine is applied more technically and mechanically and on the other hand, effort is necessary not only for controlling the disease but also for increasing the quality of the life of patients. Quinolone comprise a relatively large, growing and most interesting group of antibacterial drugs which have made a major impact on the field of antimicrobial chemotherapy, particularly in the past few years. This is due to their potentiality offer many of the attributes of an ideal antibiotic, combining high potency, a broad spectrum of activity, good bioavailability, oral and intravenous formulations, high serum levels, a large volume of distribution indicating concentration in tissues and a potentially low incidence of side-effects. More researches have attempted to make these potential attributes continuously in the field of bacterial infections. After reviewing the current position on bacterial as well as tubercle bacillus, attempt was done, based on the above mentioned facts and explore some new derivatives of fluoroquinolone by synthesizing and evaluating the targeted bacterial organisms. So, it is desired the efficacy of new fluoroquinolone derivatives for the treatment of tuberculosis.
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