Design, synthesis and antibacterial activity of 9-aryl-6-(2-naphthyl) [1,2,4]triazolo[4,3-a][1,8]naphthyridines
By: Challa, Pradeep Kumar
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Contributor(s): Ega, Jagadeesh Kumar.
Publisher: New Delhi CSIR 2021Edition: Vol.60(B), June.Description: 901-905p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here
In:
Indian journal of chemistry (Section B)Summary: A concise and highly efficient procedure has been described for the synthesis of 9-aryl-6-(2-naphthyl)[1,2,4] triazolo[4,3-a][1,8]naphthyridines8 by the oxidation of the corresponding aryl aldehyde1-[3-(2-naphthyl) [1,8]naphthyridin- 2-yl]hydrazones 7 using silica gel supported ferric chloride (SiO2-FeCl3) in solvent-free conditions under microwave irradiation. The desired products are obtained in very good yields and in a state of high purity. The structure of compounds 3-8 have been confirmed by their spectroscopic (IR, 1H NMR and MS) and analytical data. The compounds 8a-j have been screened for their antibacterial activity.
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-0278 |
A concise and highly efficient procedure has been described for the synthesis of 9-aryl-6-(2-naphthyl)[1,2,4] triazolo[4,3-a][1,8]naphthyridines8 by the oxidation of the corresponding aryl aldehyde1-[3-(2-naphthyl) [1,8]naphthyridin- 2-yl]hydrazones 7 using silica gel supported ferric chloride (SiO2-FeCl3) in solvent-free conditions under microwave irradiation. The desired products are obtained in very good yields and in a state of high purity. The structure of compounds 3-8 have been confirmed by their spectroscopic (IR, 1H NMR and MS) and analytical data. The compounds 8a-j have been screened for their antibacterial activity.
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