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Biological evaluation of some novel chalcones and their derivatives

By: Thamizhthendral, M.
Publisher: New Delhi CSIR 2021Edition: Vol.60(B), Aug.Description: 1132-1136p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here In: Indian journal of chemistry (Section B)Summary: Chalcones, (E)-N-(4-(4,6-dichloro-1,3,5 –triazin-2-ylamino) phenyl)-3-(4 methoxy-phenyl) acrylamide 4a-c have been prepared by employing Claisen-Schmidt condensation. Further, these chalcones 4a-c on reaction with malononitrile afford cyano-pyridines 5a-c respectively. The constitution of newly synthesised compounds have been characterized on the basis of their IR, 1H and 13C NMR spectral data. These synthesized compounds have been screened for their antibacterial and larvicidal activity.
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Chalcones, (E)-N-(4-(4,6-dichloro-1,3,5 –triazin-2-ylamino) phenyl)-3-(4 methoxy-phenyl) acrylamide 4a-c have been prepared by employing Claisen-Schmidt condensation. Further, these chalcones 4a-c on reaction with malononitrile afford cyano-pyridines 5a-c respectively. The constitution of newly synthesised compounds have been characterized on the basis of their IR, 1H and 13C NMR spectral data. These synthesized compounds have been screened for their antibacterial and larvicidal activity.

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