Delivery of a bioactive photosensitizer to natural DNA using γ-cyclodextrin as carrier
By: Kundu, Pronab
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Contributor(s): Mondal, Tirtha.
Publisher: New Delhi CSIR 2019Edition: Vol.58(B), Feb.Description: 147-156p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here
In:
Indian journal of chemistry (Section B)Summary: A challenging goal of targeted drug delivery is to discover novel administrating route for the delivery of bioactive molecules/drugs in the field of pharmaceutical, medicinal and biophysical research. Delivery of a cationic photosensitizer, namely, phenosafranin (PSF), to the most relevant biomolecular target DNA using nanocarrier, γ-cyclodextrin (γ-CD), has been explored via various steady state and time resolved fluorometric as well as other spectroscopic techniques. The detailed fluorometric studies including DNA helix melting experiments divulge that the binding affinity of probe with the target (DNA) is order of magnitude larger than with the carrier (γ-CD). This leads to the release of the probe from the carrier cyclodextrin to bind with the DNA. Endogenous activation, in terms of competitive binding affinity, has been exploited for this purpose. This work qualitatively illustrates that the γ-cyclodextrin can be used as a safe and potential drug delivery system (DDS) for drug targeting towards DNA.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-0294 |
A challenging goal of targeted drug delivery is to discover novel administrating route for the delivery of bioactive molecules/drugs in the field of pharmaceutical, medicinal and biophysical research. Delivery of a cationic photosensitizer, namely, phenosafranin (PSF), to the most relevant biomolecular target DNA using nanocarrier, γ-cyclodextrin (γ-CD), has been explored via various steady state and time resolved fluorometric as well as other spectroscopic techniques. The detailed fluorometric studies including DNA helix melting experiments divulge that the binding affinity of probe with the target (DNA) is order of magnitude larger than with the carrier (γ-CD). This leads to the release of the probe from the carrier cyclodextrin to bind with the DNA. Endogenous activation, in terms of competitive binding affinity, has been exploited for this purpose. This work qualitatively illustrates that the γ-cyclodextrin can be used as a safe and potential drug delivery system (DDS) for drug targeting towards DNA.
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