Synthesis and antimicrobial importance of oxazine bearing pyridine scaffold
By: Desai, N. C
.
Contributor(s): Bhatt, N. B.
Publisher: New Delhi CSIR 2019Edition: Vol.58(B), April.Description: 527-540p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here
In:
Indian journal of chemistry (Section B)Summary: A highly efficient method for the synthesis of 1-((1-(4-(2H-benzo[e][1,3]oxazin-3(4H)-yl)phenyl)ethylidene)amino)-6-((arylidene)amino)-4-(3-nitrophenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles is described. The structures have been confirmed by IR, 1H and 13C NMR, and mass spectral techniques. The synthesized compounds have been tested for antimicrobial activity. The title compounds 4a-o have been studied against strains of bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pyogenes) and fungi (Candida albicans, Aspergillus niger and Aspergillus clavatus) by serial dilution method. Compounds 4b (-2-OH), 4f (-4-NO2), 4h (-3-Cl), 4j (-4-OCH3), 4l (-4-OH-3-OCH3) and 4m (-N,N’-(CH3)2) exhibit good in vitro antimicrobial activity.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-0328 |
A highly efficient method for the synthesis of 1-((1-(4-(2H-benzo[e][1,3]oxazin-3(4H)-yl)phenyl)ethylidene)amino)-6-((arylidene)amino)-4-(3-nitrophenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles is described. The structures have been confirmed by IR, 1H and 13C NMR, and mass spectral techniques. The synthesized compounds have been tested for antimicrobial activity. The title compounds 4a-o have been studied against strains of bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pyogenes) and fungi (Candida albicans, Aspergillus niger and Aspergillus clavatus) by serial dilution method. Compounds 4b (-2-OH), 4f (-4-NO2), 4h (-3-Cl), 4j (-4-OCH3), 4l (-4-OH-3-OCH3) and 4m (-N,N’-(CH3)2) exhibit good in vitro antimicrobial activity.
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