Caffeine: A green, natural and biodegradable catalyst for convenient and expedient eco-safe synthesis of 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives under solvent-free conditions
By: Mohamadpour, Farzaneh
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Publisher: New Delhi CSIR 2019Edition: Vol.58(B), Dec.Description: 1398-1406p.Subject(s): GENERAL CHEMISTRYOnline resources: Click here
In:
Indian journal of chemistry (Section B)Summary: A green, convenient, highly versatile and solvent-free synthetic route for caffeine catalyzed one-pot multi-component synthesis of biologically active 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aryl aldehydes and malononitrile has been studied. The green, natural, biodegradable and inexpensive catalyst, eco-safe reaction, solvent-free conditions, avoidance of hazardous or toxic catalysts, simplicity of operation and work-up procedures with no necessity of chromatographic purification steps, the availability and ease of handling of this solid catalyst and good to high yields are the notable benefits for the highly efficient synthesis of these products.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-0349 |
A green, convenient, highly versatile and solvent-free synthetic route for caffeine catalyzed one-pot multi-component synthesis of biologically active 1H-pyrazolo [1,2-b] phthalazine-5,10-dione derivatives via one-pot four-component condensation reaction of phthalimide, hydrazine monohydrate, aryl aldehydes and malononitrile has been studied. The green, natural, biodegradable and inexpensive catalyst, eco-safe reaction, solvent-free conditions, avoidance of hazardous or toxic catalysts, simplicity of operation and work-up procedures with no necessity of chromatographic purification steps, the availability and ease of handling of this solid catalyst and good to high yields are the notable benefits for the highly efficient synthesis of these products.
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