Computational molecular modelling of 2-aminobenzimidazole derivatives: strong successor of hypoglycaemic agent
By: Sreeja, S
.
Contributor(s): Anton Smith, A.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2021Edition: Vol.13(9).Description: 16-21p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective: The present study was aimed to design different analogues of 2-aminobenzimidazole and find the binding ability by Insilico method. Methods: Various soft wares like Chemsketch, Molinspiration, PASS, and Discovery studio were used to design the proposed derivatives. Evaluation of binding activity against different receptors was detected and checked their physicochemical properties for binding.Results: In this study, we designed different analogs of 2-aminobenzimidazole into a ligand having a binding affinity with alpha-glucosidase, Dipeptidyl–peptidase 4(DPP4), Peroximase proliferator-activated receptor gamma (PPARγ), and Insulin-like growth factor 1(IGF-1) receptor. The designed ten derivatives showed a significant binding capacity to the concerned receptors. Conclusion: These results pointed that the designed proposed derivatives promising hypoglycaemic activity.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-0424 |
Objective: The present study was aimed to design different analogues of 2-aminobenzimidazole and find the binding ability by Insilico method. Methods: Various soft wares like Chemsketch, Molinspiration, PASS, and Discovery studio were used to design the proposed derivatives. Evaluation of binding activity against different receptors was detected and checked their physicochemical properties for binding.Results: In this study, we designed different analogs of 2-aminobenzimidazole into a ligand having a binding affinity with alpha-glucosidase, Dipeptidyl–peptidase 4(DPP4), Peroximase proliferator-activated receptor gamma (PPARγ), and Insulin-like growth factor 1(IGF-1) receptor. The designed ten derivatives showed a significant binding capacity to the concerned receptors. Conclusion: These results pointed that the designed proposed derivatives promising hypoglycaemic activity.
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