Analysis of bio-active compounds present in the leaves and stem of trichosanthes roxb. Using GC-MS technique with respect to its anti-inflammatory action
By: Aghil, Soorya Aravindakshan
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Contributor(s): Thangavel, Sekar.
Publisher: M P Innovare Academic Sciences Pvt Ltd 2021Edition: Vol.13(1).Description: 7-13p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
International journal of pharmacy and pharmaceutical scienceSummary: Objective: Structuralelucidation studies on Trichosanthes lobata ethyl acetate and methanol extracts of leaf and stem parts through Gas Chromatography-Mass Spectrometry (GC-MS) technique with respect to anti-inflammatory potential. Methods: Extracts obtained with shade dried and powdered samples in successive solvent extraction using ethyl acetate and methanol by Soxhlet apparatus and subjected to GC-MS analysis and interpreted for its anti-inflammatory compounds. Results: The study revealed that the extraction solvent used was able to recover compound of classes such as organic acid esters and conjugated alkaloids in larger quantities than other classes of compounds and they varied with leaf and stem and also with the polarity of solvents used. In total compounds identified, GC-MS profile of the Ethyl Acetate leaf extract of T.lobata contained41compounds, stem extract contained 45 compounds which have reported bioassays in PubChem. Whereas GC-MS profile of methanol leaf extract of T.lobata contained66 compounds and stem extract contained 46 compounds having bioassay reports in PubChem. A large number of phytochemical peaks with good area percentage were found in methanolic extract. We were also able to find out potent anti-inflammatory compounds includingOctanoic acid, Dodecanoic acid, Octadecane, Enoic acid, Hexanoic acid, Quinazolin-8-one, Ilicic acid, Pentadecanoic acid, Oxaspiro, Benzeneacetic acid,etc. from the extracts. Conclusion: T. lobata contains phytocompounds against inflammation which may serve as a new drug lead of natural products origin in future and make it employable in modern pharmacological practices.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-0444 |
Objective: Structuralelucidation studies on Trichosanthes lobata ethyl acetate and methanol extracts of leaf and stem parts through Gas Chromatography-Mass Spectrometry (GC-MS) technique with respect to anti-inflammatory potential. Methods: Extracts obtained with shade dried and powdered samples in successive solvent extraction using ethyl acetate and methanol by Soxhlet apparatus and subjected to GC-MS analysis and interpreted for its anti-inflammatory compounds. Results: The study revealed that the extraction solvent used was able to recover compound of classes such as organic acid esters and conjugated alkaloids in larger quantities than other classes of compounds and they varied with leaf and stem and also with the polarity of solvents used. In total compounds identified, GC-MS profile of the Ethyl Acetate leaf extract of T.lobata contained41compounds, stem extract contained 45 compounds which have reported bioassays in PubChem. Whereas GC-MS profile of methanol leaf extract of T.lobata contained66 compounds and stem extract contained 46 compounds having bioassay reports in PubChem. A large number of phytochemical peaks with good area percentage were found in methanolic extract. We were also able to find out potent anti-inflammatory compounds includingOctanoic acid, Dodecanoic acid, Octadecane, Enoic acid, Hexanoic acid, Quinazolin-8-one, Ilicic acid, Pentadecanoic acid, Oxaspiro, Benzeneacetic acid,etc. from the extracts. Conclusion: T. lobata contains phytocompounds against inflammation which may serve as a new drug lead of natural products origin in future and make it employable in modern pharmacological practices.
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