Multi-unit compressible coated pellets
By: Vidyadhara, Suryadevara
.
Contributor(s): Doppalapudi, Sandeep.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.53(2), Jan.Description: 11-16p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Pharma timesSummary: Modified oral drug delivery systems play a significant role in preparation of novel oral drug delivery systems. As conventional immediate
release dosage forms have short duration of action, research on modified systems became extensive. Pellets are formulated to prepare
oral controlled release dosage forms with gastro-retentive or sustained-release properties. To attain such properties, pellets must be
coated and multi-unit compressible tablets must be prepared. They are advantageous in many aspects like masking of taste, avoidance
of dose dumping, bioavailability enhancement along with uniform drug absorption. Several factors like nature and amount of polymer,
cushioning excipients, core pellets and equipment used, influence the designing of tablets. The polymers used for coating depend
upon the type of drug release. The major problem in the preparation of compressible coated pellets is compression. When pellets are
compressed, there is a chance for loss of coating. So, the method employed should also preserve coating even after the compression
of pellets into tablets. The drug uniformity in pellets is a primary prerequisite, which avoids dose dumping. Blending process, blenders
used and the compaction also affects the drug mixing. The current review discusses the advantages, preparation techniques and
various factors affecting the formulation of multi-unit compressible coated tablets
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-0865 |
Modified oral drug delivery systems play a significant role in preparation of novel oral drug delivery systems. As conventional immediate
release dosage forms have short duration of action, research on modified systems became extensive. Pellets are formulated to prepare
oral controlled release dosage forms with gastro-retentive or sustained-release properties. To attain such properties, pellets must be
coated and multi-unit compressible tablets must be prepared. They are advantageous in many aspects like masking of taste, avoidance
of dose dumping, bioavailability enhancement along with uniform drug absorption. Several factors like nature and amount of polymer,
cushioning excipients, core pellets and equipment used, influence the designing of tablets. The polymers used for coating depend
upon the type of drug release. The major problem in the preparation of compressible coated pellets is compression. When pellets are
compressed, there is a chance for loss of coating. So, the method employed should also preserve coating even after the compression
of pellets into tablets. The drug uniformity in pellets is a primary prerequisite, which avoids dose dumping. Blending process, blenders
used and the compaction also affects the drug mixing. The current review discusses the advantages, preparation techniques and
various factors affecting the formulation of multi-unit compressible coated tablets
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