Herb-drug interaction: need of the hour
By: Sathiyanarayanan, L
.
Contributor(s): Addi, Mohan.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.53(7), July.Description: 20-24p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Pharma timesSummary: The usage of herbal remedies has become very common and the interest of researchers has tremendously increased in herbal research.
Herbs are believed to be free from side effects compared to synthetic drugs, thus their usage is increasing day by day. The concomitant
use of herbal remedies along with synthetic prescription drugs is commonly observed especially in chronic disease conditions such
as diabetes, arthritis, obesity, etc. However, herbs are known to interact with drugs when administered concomitantly. Several studies
have been reported for such herb-drug interactions that include both pharmacokinetic and pharmacodynamics interactions. One of the
basics for such herb-drug interaction studies is CYP450 enzymes. The common metabolic enzymes are considered as one important
factor while designing such studies. However, various methodologies have been reported for herb-drug interaction studies. Despite the
advanced methodologies and analytical techniques, there are a lot of challenges in carrying out herb-drug interaction studies including
variations in CYP enzymes in laboratory animals and humans, lack of bioanalytical methods, complex biological events, etc. However,
systematic and focused studies should be designed to explore potential herb-drug interactions. Undoubtedly, this area of research is
not much explored and needs to be focused on.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-0886 |
The usage of herbal remedies has become very common and the interest of researchers has tremendously increased in herbal research.
Herbs are believed to be free from side effects compared to synthetic drugs, thus their usage is increasing day by day. The concomitant
use of herbal remedies along with synthetic prescription drugs is commonly observed especially in chronic disease conditions such
as diabetes, arthritis, obesity, etc. However, herbs are known to interact with drugs when administered concomitantly. Several studies
have been reported for such herb-drug interactions that include both pharmacokinetic and pharmacodynamics interactions. One of the
basics for such herb-drug interaction studies is CYP450 enzymes. The common metabolic enzymes are considered as one important
factor while designing such studies. However, various methodologies have been reported for herb-drug interaction studies. Despite the
advanced methodologies and analytical techniques, there are a lot of challenges in carrying out herb-drug interaction studies including
variations in CYP enzymes in laboratory animals and humans, lack of bioanalytical methods, complex biological events, etc. However,
systematic and focused studies should be designed to explore potential herb-drug interactions. Undoubtedly, this area of research is
not much explored and needs to be focused on.
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