Improved performance of carbamazepine and benzodiazepine by oxygen enrichment through perfluorodecalin for lennox-gastaut type of seizures
By: Natchimuthu, V
.
Contributor(s): Ravi S.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(4), July-Aug.Description: 848-855p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Lennox-Gastaut syndrome is commonly characterized by a triad of features including multiple seizure
types, intellectual disability or regression. The long-term prognosis for Lennox-Gastaut syndrome is
generally poor due to uncontrolled seizures. Lennox-Gastaut syndrome type of seizures is epilepsy which
is due to abnormal vibrations occurring in seizures. During the time of such abnormal vibrations, both the
seizures and the lungs suffer a lack in oxygen content to a considerable extent. This results in prolonged
vibrations and loses of nervous control. As a neuro-lung protective strategy, a novel attempt has been
made to enrich both seizures and lungs with oxygen content through the support of perfluorodecalin
(an excellent oxygen carrier) C10
F18 along with an enhancement in the antiepileptic activity by the two
chosen antiepileptic drugs carbamazepine and benzodiazepine. The ultraviolet-visible spectrophotometer,
fluorescence spectrograph, ultrasonic laser diffraction and scanning electron microscope studies reveals
the co-existence of fluorine and drug in the emulsion produced by the sonication of both perfluorodecalin
and the drug together. The presence of adequate fluorine and carbon play a catalytic role in ensuring the
oxygen content and the antiepileptic activity of drug components.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2022-0938 |
Lennox-Gastaut syndrome is commonly characterized by a triad of features including multiple seizure
types, intellectual disability or regression. The long-term prognosis for Lennox-Gastaut syndrome is
generally poor due to uncontrolled seizures. Lennox-Gastaut syndrome type of seizures is epilepsy which
is due to abnormal vibrations occurring in seizures. During the time of such abnormal vibrations, both the
seizures and the lungs suffer a lack in oxygen content to a considerable extent. This results in prolonged
vibrations and loses of nervous control. As a neuro-lung protective strategy, a novel attempt has been
made to enrich both seizures and lungs with oxygen content through the support of perfluorodecalin
(an excellent oxygen carrier) C10
F18 along with an enhancement in the antiepileptic activity by the two
chosen antiepileptic drugs carbamazepine and benzodiazepine. The ultraviolet-visible spectrophotometer,
fluorescence spectrograph, ultrasonic laser diffraction and scanning electron microscope studies reveals
the co-existence of fluorine and drug in the emulsion produced by the sonication of both perfluorodecalin
and the drug together. The presence of adequate fluorine and carbon play a catalytic role in ensuring the
oxygen content and the antiepileptic activity of drug components.
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