Mass spectrometric study of naproxen dimer anions generated from racemeate and pure enantiomers
By: Pracz, Monika
.
Contributor(s): Magdalena, Franska.
Publisher: Haryana International Science Press 2021Edition: Vo.12(1), Jan-June.Description: 55-62p.Subject(s): PHARMACEUTICS
In:
Indian journal of pharmaceuticsSummary: The behaviour of naproxen dimer onions([2Napr-H]) was studied by electrospray ionization mass spectrometry. Three different analyses were performed, namely direct inlet MS and HPLC/MS (performed for different cone voltages) as well as CID MS/MS (fro different collision energies). The results obtained have shown that naproxen dimer anions generated from pure enantiomers are more stable than dimer generated from racemate. This finding indicates that in dimers the interactions between aromatic substituents take place. This observation can be used to differentiate between pure enantiomer and racemate.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-1028 |
The behaviour of naproxen dimer onions([2Napr-H]) was studied by electrospray ionization mass spectrometry. Three different analyses were performed, namely direct inlet MS and HPLC/MS (performed for different cone voltages) as well as CID MS/MS (fro different collision energies). The results obtained have shown that naproxen dimer anions generated from pure enantiomers are more stable than dimer generated from racemate. This finding indicates that in dimers the interactions between aromatic substituents take place. This observation can be used to differentiate between pure enantiomer and racemate.
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