Probiotics on intestinal flora disturbance and bacterial translocation in mice with inflammatory bowel disease
By: Ding, Liying
.
Contributor(s): Chen, Xiuting.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(6), Nov-Dec.Description: 1174-1180p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Inflammatory bowel disease is becoming more and more common in western countries and less common in
China. However, with the change of dietary structure, the incidence of inflammatory bowel disease is also
increasing in China. It will cause abdominal pain, diarrhea and mucus, pus and blood, which are repeatedly
delayed and difficult to alleviate. To explore the effectiveness of probiotics in the treatment of inflammatory
bowel disease, Lactobacillus plantarum in probiotics and fifteen 8 w old female mice were selected for
the experiment. We divided the mice into three groups: blank control group, interleukin-10 group and
interleukin-10+Lactobacillus plantarum group. The interleukin-10+Lactobacillus plantarum group was
gavaged with 0.5 ml of Lactobacillus plantarum bacterial solution (1.0×109 CFU/ml) every d. The blank
control group and interleukin-10 group were gavaged with 0.5 ml of Ringer buffer for 4 consecutive w and
compared the changes caused by Lactobacillus plantarum on Bifidobacterium, Lactobacillus, Clostridium
perfringens and Enterobacter in the intestinal flora of mice and the changes caused by Lactobacillus
plantarum on the intestinal flora effect of bacterial translocation in membranous lymph nodes and spleen.
We found that the content of Enterobacter in the blank control group was the lowest at all three time points,
with an average of 6. The content of Enterobacter in the interleukin-10+Lactobacillus plantarum group
and the interleukin-10 group was 6.5 and 6.6 respectively, at the beginning of 0 w and 6.3 at the beginning
of 2 w but after the 4 w, the content of Enterobacter in the two groups became 6.4 and 6.7, the difference
increasedy.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-1230 |
Inflammatory bowel disease is becoming more and more common in western countries and less common in
China. However, with the change of dietary structure, the incidence of inflammatory bowel disease is also
increasing in China. It will cause abdominal pain, diarrhea and mucus, pus and blood, which are repeatedly
delayed and difficult to alleviate. To explore the effectiveness of probiotics in the treatment of inflammatory
bowel disease, Lactobacillus plantarum in probiotics and fifteen 8 w old female mice were selected for
the experiment. We divided the mice into three groups: blank control group, interleukin-10 group and
interleukin-10+Lactobacillus plantarum group. The interleukin-10+Lactobacillus plantarum group was
gavaged with 0.5 ml of Lactobacillus plantarum bacterial solution (1.0×109 CFU/ml) every d. The blank
control group and interleukin-10 group were gavaged with 0.5 ml of Ringer buffer for 4 consecutive w and
compared the changes caused by Lactobacillus plantarum on Bifidobacterium, Lactobacillus, Clostridium
perfringens and Enterobacter in the intestinal flora of mice and the changes caused by Lactobacillus
plantarum on the intestinal flora effect of bacterial translocation in membranous lymph nodes and spleen.
We found that the content of Enterobacter in the blank control group was the lowest at all three time points,
with an average of 6. The content of Enterobacter in the interleukin-10+Lactobacillus plantarum group
and the interleukin-10 group was 6.5 and 6.6 respectively, at the beginning of 0 w and 6.3 at the beginning
of 2 w but after the 4 w, the content of Enterobacter in the two groups became 6.4 and 6.7, the difference
increasedy.
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