Evaluation of anti-malarial effect of moringa oleifera (lam) in plasmodium yoelii infected mice
By: Shrivastava, Megha
.
Contributor(s): Arti Prasad.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(6), Nov-Dec.Description: 1221-1228p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Malaria kills a lot of people every year in the world, yet this has been observed with little progress in
controlling this disease. Moreover, the number of cases is increasing, resulting from the rise of drug-
resistant parasites and insecticide-resistant mosquitoes. In the present study the antimalarial efficiency
of flowers and leaves of the Moringa oleifera (Lam.) plant was evaluated against rodent malaria parasite:
Plasmodium yoelii (Chloroquine resistant N-67 strain) infected Swiss albino mice. For the study, crude
extracts of flowers and leaves of the Moringa oleifera (Lam.) plant were given at different doses i.e., 125,
250, 500 and 1000 mg/kg to Plasmodium yoelii infected Swiss albino mice, then various parameters llike
percent of suppression of parasites, haematological parameters, survival time and body weight of mice,
were determined. Percent of suppression of parasites were evaluated by observing Giemsa stained blood
smears, which were prepared from different treated groups of experimental mice and haematological
testing was done with an automated haematological analyser. The percent of suppression exerted by the
flower and leaf against Plasmodium yoelii count ranged between 59 to 41% and 56 to 32%, respectively.
Both extracts were found to give positive results as they prevented the major changes in haematological
parameters i.e., count of red blood cells, white blood cells and platelets, haemoglobin concentration
and haematocrit value which occurred due to Plasmodium infection. Maximum antimalarial effect was
observed with the highest dose of the flower extract at 1000 mg/kg followed by leaf extract at the same
dose. The crude extract prolongs the survival time of mice as well as prevents body weight loss compared
to negative control groups. The results are collectively indicated that the Moringa oleifera (Lam.) plant has
a promising anti plasmodial activity against Plasmodium yoelii. Thus, it might be considered as a potential
source for the development of novel antimalarial agents.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-1243 |
Malaria kills a lot of people every year in the world, yet this has been observed with little progress in
controlling this disease. Moreover, the number of cases is increasing, resulting from the rise of drug-
resistant parasites and insecticide-resistant mosquitoes. In the present study the antimalarial efficiency
of flowers and leaves of the Moringa oleifera (Lam.) plant was evaluated against rodent malaria parasite:
Plasmodium yoelii (Chloroquine resistant N-67 strain) infected Swiss albino mice. For the study, crude
extracts of flowers and leaves of the Moringa oleifera (Lam.) plant were given at different doses i.e., 125,
250, 500 and 1000 mg/kg to Plasmodium yoelii infected Swiss albino mice, then various parameters llike
percent of suppression of parasites, haematological parameters, survival time and body weight of mice,
were determined. Percent of suppression of parasites were evaluated by observing Giemsa stained blood
smears, which were prepared from different treated groups of experimental mice and haematological
testing was done with an automated haematological analyser. The percent of suppression exerted by the
flower and leaf against Plasmodium yoelii count ranged between 59 to 41% and 56 to 32%, respectively.
Both extracts were found to give positive results as they prevented the major changes in haematological
parameters i.e., count of red blood cells, white blood cells and platelets, haemoglobin concentration
and haematocrit value which occurred due to Plasmodium infection. Maximum antimalarial effect was
observed with the highest dose of the flower extract at 1000 mg/kg followed by leaf extract at the same
dose. The crude extract prolongs the survival time of mice as well as prevents body weight loss compared
to negative control groups. The results are collectively indicated that the Moringa oleifera (Lam.) plant has
a promising anti plasmodial activity against Plasmodium yoelii. Thus, it might be considered as a potential
source for the development of novel antimalarial agents.
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