Antioxidant, antimicrobial and cytotoxic activities of salvia verticillata l. Extracts
By: Barjaktarevic, Ana
.
Contributor(s): Cirovic, Tijana.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(6), Nov-Dec.Description: 1280-1287p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: Salvia verticillata L. is a well-known plant from the family Lamiaceae. The purpose of this research was
to analyze the cytotoxic, antioxidant and antimicrobial activities of chloroform and petroleum ether root
extracts of Salvia verticillata. The total content of phenolic compounds and flavonoids were determined in
both of the extracts. The antioxidant activity was estimated in vitro using different assays. The antimicrobial
potential was tested against different test strains using micro-well dilution assay. The cytotoxic activity was
evaluated on epithelial, human breast cancer cell line MDA-MB-231 and human colorectal carcinoma cell
line HCT 116 by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. The extracts
showed similar antioxidant activity. The values for the antimicrobial activity differed depending on the
microbial strain as well on the solvent used. There were significant differences in cytotoxic effect on
investigated cell lines depending of the concentration. Half maximal inhibitory concentration value for
chloroform extract was 77.16 μg/ml for MDA-MB-231 cell line and 105.08 μg/ml for the HCT 116 cell
line. Half maximal inhibitory concentration value for petroleum ether extract was 30.90 μg/ml for MDA-
MB-231 cell line and 44.28 μg/ml for the HCT 116 cell line.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-1252 |
Salvia verticillata L. is a well-known plant from the family Lamiaceae. The purpose of this research was
to analyze the cytotoxic, antioxidant and antimicrobial activities of chloroform and petroleum ether root
extracts of Salvia verticillata. The total content of phenolic compounds and flavonoids were determined in
both of the extracts. The antioxidant activity was estimated in vitro using different assays. The antimicrobial
potential was tested against different test strains using micro-well dilution assay. The cytotoxic activity was
evaluated on epithelial, human breast cancer cell line MDA-MB-231 and human colorectal carcinoma cell
line HCT 116 by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay. The extracts
showed similar antioxidant activity. The values for the antimicrobial activity differed depending on the
microbial strain as well on the solvent used. There were significant differences in cytotoxic effect on
investigated cell lines depending of the concentration. Half maximal inhibitory concentration value for
chloroform extract was 77.16 μg/ml for MDA-MB-231 cell line and 105.08 μg/ml for the HCT 116 cell
line. Half maximal inhibitory concentration value for petroleum ether extract was 30.90 μg/ml for MDA-
MB-231 cell line and 44.28 μg/ml for the HCT 116 cell line.
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