Isolation, structural elucidation and therapeutic potentials of root of cucurbita pepo
By: Ekeocha, P. A
.
Contributor(s): Ezeh, Co.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(6), Nov-Dec.Description: 1288-1294p.Subject(s): PHARMACEUTICSOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: The roots of Cucurbita pepo were investigated with the aim of identifying bioactive constituents with
therapeutic potentials. To achieve this, the roots of Cucurbita pepo were harvested, washed, air dried and
grounded into the powder. The ground material was extracted using hexane, ethyl acetate and methanol.
The extracts were fractionated using column chromatography and fractions were monitored using thin
layer chromatography. The fractions were characterised using proton nuclear magnetic resonance and
carbon-13 nuclear magnetic resonance spectroscopy. Phytochemical screening showed that the extracts
contained sterols and terpenoids, alkaloids, resins, flavonoids, saponins and carbohydrates. Nuclear
magnetic resonance analysis led to the identification of hexadecanoic acid or palmitic acid, alpha-
spinasterol and squalene. Some of these compounds may represent a new pharmacological approach in
the development of novel and adjuvant therapy for several medical conditions.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
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Articles Abstract Database
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School of Pharmacy Archieval Section | Not for loan | 2022-1253 |
The roots of Cucurbita pepo were investigated with the aim of identifying bioactive constituents with
therapeutic potentials. To achieve this, the roots of Cucurbita pepo were harvested, washed, air dried and
grounded into the powder. The ground material was extracted using hexane, ethyl acetate and methanol.
The extracts were fractionated using column chromatography and fractions were monitored using thin
layer chromatography. The fractions were characterised using proton nuclear magnetic resonance and
carbon-13 nuclear magnetic resonance spectroscopy. Phytochemical screening showed that the extracts
contained sterols and terpenoids, alkaloids, resins, flavonoids, saponins and carbohydrates. Nuclear
magnetic resonance analysis led to the identification of hexadecanoic acid or palmitic acid, alpha-
spinasterol and squalene. Some of these compounds may represent a new pharmacological approach in
the development of novel and adjuvant therapy for several medical conditions.
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