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Indian journal of pharmaceutical sciences1308november-december 2021 evaluation of gut microbial changes in human and murine models in response to antibiotics

By: Kumar, S.
Contributor(s): Perumal, N.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2021Edition: Vol.83(6), Nov-Dec.Description: 1308-1314p.Subject(s): PHARMACEUTICSOnline resources: Click here In: Indian journal of pharmaceutical sciencesSummary: Widespread usage of antibiotics disrupted the host bacterial mutualism in the human intestine. The antibiotic alterations can drive the functionality of the gut microbiota towards a state similar to those observed under various disease states in humans. The emergence of antibiotic-resistant bacteria further spurred the development of the antimicrobial crisis all over the world. Antibiotics have an essential role in treating various diseases. To understand the intricate relationship between antibiotics and human gut microbiota, the basic understanding of the microbial signature of gut dysbiosis in human patients and murine models in response to antibiotics treatment is very crucial. Therefore, we examined the effects of most commonly used antibiotics on human and murine gut microbiota, when administered alone or in a combination, under this article.
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Widespread usage of antibiotics disrupted the host bacterial mutualism in the human intestine. The
antibiotic alterations can drive the functionality of the gut microbiota towards a state similar to those
observed under various disease states in humans. The emergence of antibiotic-resistant bacteria further
spurred the development of the antimicrobial crisis all over the world. Antibiotics have an essential role
in treating various diseases. To understand the intricate relationship between antibiotics and human gut
microbiota, the basic understanding of the microbial signature of gut dysbiosis in human patients and
murine models in response to antibiotics treatment is very crucial. Therefore, we examined the effects of
most commonly used antibiotics on human and murine gut microbiota, when administered alone or in a
combination, under this article.

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